MAPK Genes Interact with Diet and Lifestyle Factors to Alter Risk of Breast Cancer: The Breast Cancer Health Disparities Study
| العنوان: | MAPK Genes Interact with Diet and Lifestyle Factors to Alter Risk of Breast Cancer: The Breast Cancer Health Disparities Study |
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| المؤلفون: | Abbie Lundgreen, Roger K. Wolff, Martha L. Slattery, Mariana C. Stern, Kathy B. Baumgartner, Gabriela Torres-Mejía, Anna R. Giuliano, Lisa M. Hines, Esther M. John |
| المصدر: | Nutrition and Cancer. 67:292-304 |
| بيانات النشر: | Informa UK Limited, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Dietary Fiber, Oncology, Cancer Research, Medicine (miscellaneous), Estrogen receptor, Body Mass Index, Mitogen-Activated Protein Kinase 14, Risk Factors, Registries, Mitogen-Activated Protein Kinase 1, education.field_of_study, Nutrition and Dietetics, Middle Aged, MAP Kinase Kinase Kinases, Menopause, Receptors, Estrogen, Dual-Specificity Phosphatases, Female, Mitogen-Activated Protein Kinases, Receptors, Progesterone, Adult, medicine.medical_specialty, Population, Breast Neoplasms, Single-nucleotide polymorphism, MAP Kinase Kinase Kinase 2, Biology, Polymorphism, Single Nucleotide, Article, Folic Acid, Breast cancer, Population Groups, Internal medicine, Progesterone receptor, Southwestern United States, medicine, Humans, Mitogen-Activated Protein Kinase 8, education, Life Style, Mexico, Aged, Case-control study, Health Status Disparities, medicine.disease, Dietary Fats, Diet, Endocrinology, Case-Control Studies, Mitogen-Activated Protein Kinase Phosphatases, San Francisco, Energy Intake, Body mass index |
| الوصف: | Mitogen-activated protein kinases (MAPK) are integration points for multiple biochemical signals. We evaluated 13 MAPK genes with breast cancer risk and determined if diet and lifestyle factors mediated risk. Data from 3 population-based case-control studies conducted in Southwestern United States, California, and Mexico included 4183 controls and 3592 cases. Percent Indigenous American (IA) ancestry was determined from 104 ancestry informative markers. The adaptive rank truncated product (ARTP) was used to determine the significance of each gene and the pathway with breast cancer risk, by menopausal status, genetic ancestry level, and estrogen receptor (ER)/progesterone receptor (PR) strata. MAP3K9 was associated with breast cancer overall (P(ARTP) = 0.02) with strongest association among women with the highest IA ancestry (P(ARTP) = 0.04). Several SNPs in MAP3K9 were associated with ER+/PR+ tumors and interacted with dietary oxidative balance score (DOBS), dietary folate, body mass index (BMI), alcohol consumption, cigarette smoking, and a history of diabetes. DUSP4 and MAPK8 interacted with calories to alter breast cancer risk; MAPK1 interacted with DOBS, dietary fiber, folate, and BMI; MAP3K2 interacted with dietary fat; and MAPK14 interacted with dietary folate and BMI. The patterns of association across diet and lifestyle factors with similar biological properties for the same SNPs within genes provide support for associations. |
| تدمد: | 1532-7914 0163-5581 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dae1b6a02607e8db97ac467ee17e495Test https://doi.org/10.1080/01635581.2015.990568Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....5dae1b6a02607e8db97ac467ee17e495 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15327914 01635581 |
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