التفاصيل البيبلوغرافية
العنوان:
A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry
المؤلفون:
Mary Cushman , Shad B. Smith , Patricia A. Peyser , Jorge L. Rodriguez-Gil , Struan F.A. Grant , Regina G. Ziegler , Timothy D. Howard , Imran O. Morhason-Bello , Mariaelisa Graff , Christopher S. Carlson , Cameron D. Palmer , Charleston W. K. Chiang , Evandine Rampersaud , Lisa Chu , Uma Nayak , Curtis A. Pettaway , Ye Feng , Jing Hua Zhao , Barbara V. Howard , Joanne M. Jordan , Gregory L. Burke , Melinda C. Aldrich , Dezheng Huo , Omri Gottesman , Richard S. Cooper , Sonja I. Berndt , Donna K. Arnett , Gary S. Gilkeson , M. Cristina Leske , Ulrich Broeckel , Edmond K. Kabagambe , Stephen J. Chanock , Michael J. Thun , John S. Witte , William Maixner , Adebowale Adeyemo , Oladosu Ojengbede , Sarah J. Nyante , William J. Blot , Nicholette D. Palmer , Jyotika K. Fernandes , Laura J. Rasmussen-Torvik , Julie R. Palmer , Ida J. Spruill , Wei Zheng , Ruth J. F. Loos , Guo Li , Robert C. Millikan , Donald W. Bowden , Ellen W. Demerath , Michèle M. Sale , Neil A. Zakai , Zhaoming Wang , Fang Chen , George J. Papanicolaou , Gary K. Chen , Talin Haritunians , Rajiv Nadukuru , James J. Yang , Brian E. Henderson , Sandra Deming-Halverson , Adesola Ogunniyi , David Van Den Berg , Diane L. Kamen , Phyllis J. Goodman , Eric A. Klein , Yingchang Lu , Thomas W. Winkler , Marguerite R. Irvin , Badri Padhukasahasram , Benjamin A. Rybicki , Yan V. Sun , Yii-Der Ida Chen , Temidayo O. Ogundiran , Andrew B. Singleton , Babatunde L. Salako , Vaneet Lotay , Christine B. Ambrosone , Karen C. Johnson , Michael F. Press , Neil E. Caporaso , Guillaume Lettre , Ingrid B. Borecki , Sue A. Ingles , Yonglan Zheng , Jennifer J. Hu , Leslie Bernstein , Keri L. Monda , Kristine R. Monroe , L. Keoki Williams , Thomas H. Mosley , Shamika Ketkar , Ryan W. Driver , Margaret A. Tucker , Josyf C. Mychaleckyj , Ann W. Hsing , Xiuqing Guo , Lewis H. Kuller , Patricia M. Dubbert , Kelly J. Hunt , JoAnn E. Manson , Joel N. Hirschhorn , Mara Z. Vitolins , Tamara B. Harris , Matthew A. Allison , Abdullah Kutlar , Leslie A. Lange , Yongmei Liu , Ulrike Peters , Hakon Hakonarson , Mary K. Wojczynski , Xiaofeng Zhu , Edward A. Ruiz-Narváez , Todd L. Edwards , Heather M. Ochs-Balcom , Jingzhong Ding , Albert M. Levin , W. Timothy Garvey , Digna R. Velez Edwards , Sun J. Kang , Jie Zhou , Barry I. Freedman , Sanjay R. Patel , Suh Yuh Wu , Sylvia Wassertheil-Smoller , Simin Liu , Daniel Shriner , Elizabeth K. Speliotes , Larry D. Atwood , Graham Casey , Lisa R. Yanek , Susan Redline , Lisa B. Signorello , Wei Zhao , Scott M. Williams , Bamidele O. Tayo , Kira C. Taylor , Angela Britton , Xifeng Wu , Erwin P. Bottinger , Charles N. Rotimi , Mary F. Feitosa , Joseph M. Zmuda , Curtis C. Harris , Christine Neslund-Dudas , Bruce M. Psaty , Alexander P. Reiner , Helen N. Lyon , Youfang Liu , Krista A. Zanetti , Jonathan P. Bradfield , Esther M. John , Ann G. Schwartz , Elizabeth M. Gillanders , Mike A. Nalls , Suzanne Kolb , Cathryn H. Bock , Alan B. Zonderman , David Duggan , Gerhard A. Coetzee , Charles Kooperberg , Sharon L.R. Kardia , Olufunmilayo I. Olopade , Suhn K. Rhie , John D. Carpten , Maggie C.Y. Ng , Kari E. North , Christopher A. Haiman , Barbara Nemesure , Loic Le Marchand , Christopher I. Amos , Adeyinka Ademola , Lara Sucheston , Pamela J. Schreiner , Taylor Young , Sara S. Strom , Carl D. Langefeld , Jason H. Moore , Marian L. Neuhouser , Lawrence F. Bielak , Diane M. Becker , Margaret Wrensch , Janet L. Stanford , Laurence N. Kolonel , Yan A. Meng , Margaret R. Spitz , Brendan J. Keating , Kurt Lohman , Virginia J. Howard , Guanjie Chen , Elisa V. Bandera , Quiyin Cai , Amidou N'Diaye , Stefan Ambs , Adam B. Murphy , Eric E. Schadt , Anselm Hennis , Rick A. Kittles , Caroline S. Fox , John K. Wiencke , Katherine L. Nathanson , Barbara McKnight , Michele K. Evans , Wei-Min Chen , Dena G. Hernandez , Herman A. Taylor , David S. Siscovick , Lorna H. McNeill
المصدر:
Nature genetics
بيانات النشر:
Springer Science and Business Media LLC, 2013.
سنة النشر:
2013
مصطلحات موضوعية:
Genetics , Single-nucleotide polymorphism , Genome-wide association study , Locus (genetics) , Biology , Polymorphism, Single Nucleotide , FTO gene , Linkage Disequilibrium , Article , Body Mass Index , Black or African American , Gene Frequency , Genetic Loci , Case-Control Studies , Meta-analysis , Genetic variation , Humans , Genetic Predisposition to Disease , Obesity , Body mass index , Genome-Wide Association Study , Genetic association
الوصف:
Genome-wide association studies (GWAS) have identified 36 loci associated with body mass index (BMI), predominantly in populations of European ancestry. We conducted a meta-analysis to examine the association of3.2 million SNPs with BMI in 39,144 men and women of African ancestry and followed up the most significant associations in an additional 32,268 individuals of African ancestry. We identified one new locus at 5q33 (GALNT10, rs7708584, P = 3.4 × 10(-11)) and another at 7p15 when we included data from the GIANT consortium (MIR148A-NFE2L3, rs10261878, P = 1.2 × 10(-10)). We also found suggestive evidence of an association at a third locus at 6q16 in the African-ancestry sample (KLHL32, rs974417, P = 6.9 × 10(-8)). Thirty-two of the 36 previously established BMI variants showed directionally consistent effect estimates in our GWAS (binomial P = 9.7 × 10(-7)), five of which reached genome-wide significance. These findings provide strong support for shared BMI loci across populations, as well as for the utility of studying ancestrally diverse populations.
تدمد:
1546-1718
الوصول الحر:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5da5c22b5eeaa46e00c216c7d074dac9Test https://doi.org/10.1038/ng.2608Test
حقوق:
OPEN
رقم الانضمام:
edsair.doi.dedup.....5da5c22b5eeaa46e00c216c7d074dac9
قاعدة البيانات:
OpenAIRE
