Diagnostic and Prognostic Utility of PD-1 In B Cell Lymphomas
| العنوان: | Diagnostic and Prognostic Utility of PD-1 In B Cell Lymphomas |
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| المؤلفون: | S. Muenst, S. Hoeller, N. Willi, S. Dirnhofer, A. Tzankov |
| المصدر: | Disease Markers, Vol 29, Iss 1, Pp 47-53 (2010) Disease markers |
| بيانات النشر: | Hindawi Limited, 2010. |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | Adult, Male, lcsh:R5-920, Lymphoma, B-Cell, Biochemistry (medical), Clinical Biochemistry, Programmed Cell Death 1 Receptor, General Medicine, Middle Aged, Prognosis, Immunohistochemistry, Lymphocytes, Tumor-Infiltrating, Antigens, CD, immune system diseases, hemic and lymphatic diseases, Genetics, Biomarkers, Tumor, Humans, Female, Other, Apoptosis Regulatory Proteins, lcsh:Medicine (General), Molecular Biology, Aged |
| الوصف: | Aims: Programmed death-1 (PD-1) is expressed by germinal center-associated helper T-cells and acts as a negative regulator of the immune system. PD-1 is encountered on tumor cells of angioimmunoblastic T-cell lymphoma and is a postulated diagnostic marker in chronic lymphocytic leukemia (CLL/SLL). Recent data suggest prognostic importance of PD-1 in follicular lymphoma (FL). We assessed the diagnostic potential and the prognostic importance of PD-1 in B-cell lymphomas.Methods: Distribution of PD-1+ lymphocytes in B-cell lymphomas was studied on 403 cases. Correlation with known biologic and clinical key data was performed. Prognostic cut-off scores were determined by receiver operating curve analysis. Results: PD-1+ tumor-infiltrating lymphocytes were numerous in extranodal marginal zone lymphomas and FL. Their amount decreased from FL grade 1 to grade 3 and to FL with transformation to diffuse large B-cell lymphoma. An increased amount of PD-1 tumor-infiltrating lymphocytes above the prognostic cut-off score (> 2.8%) was a positive prognostic factor of disease-specific survival (DSS) in FL-patients. Five percent of the studied 66 CLL/SLL cases showed unequivocal PD-1 positivity of neoplastic cells.Conclusions: Increased number of PD-1+ tumor-infiltrating lymphocytes is associated with significantly improved DSS in FL and may be useful to predict its heterogeneous clinical behavior. PD-1 has probably limited diagnostic value for primary histopathological CLL/SLL diagnostics. |
| وصف الملف: | text/xhtml |
| اللغة: | English |
| تدمد: | 1875-8630 0278-0240 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d5cea0fe4abd2364038411e106e08e3Test https://doaj.org/article/5196a634ed104a59b77edb443fa65d7eTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....5d5cea0fe4abd2364038411e106e08e3 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18758630 02780240 |
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