Fine needle aspiration of salivary gland carcinomas with high‐grade transformation: A multi‐institutional study of 22 cases and review of the literature
| العنوان: | Fine needle aspiration of salivary gland carcinomas with high‐grade transformation: A multi‐institutional study of 22 cases and review of the literature |
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| المؤلفون: | Esther Diana Rossi, Kathleen T. Montone, Darcy A. Kerr, Masato Nakaguro, Liron Pantanowitz, Kim Ely, Margaret L. Compton, Zubair W. Baloch, Brittany J. Holmes, Richard Cantley, Peter M. Sadow, Michiya Nishino, Rong Hu, William C. Faquin |
| المصدر: | Cancer Cytopathol |
| بيانات النشر: | Wiley, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Adult, Male, Cancer Research, Pathology, medicine.medical_specialty, Adenoid cystic carcinoma, Biopsy, Fine-Needle, 030209 endocrinology & metabolism, Article, Acinic cell carcinoma, 03 medical and health sciences, 0302 clinical medicine, medicine, Humans, Aged, Retrospective Studies, Aged, 80 and over, medicine.diagnostic_test, Salivary gland, business.industry, Middle Aged, Salivary Gland Neoplasms, medicine.disease, Parotid gland, Patient management, Secretory Carcinoma, medicine.anatomical_structure, Fine-needle aspiration, Oncology, 030220 oncology & carcinogenesis, Female, Neoplasm Grading, Differential diagnosis, business |
| الوصف: | Background High-grade transformation (HGT) is a rare process whereby conventional low- to intermediate-grade salivary gland carcinomas (SGC) transform into high-grade, poorly or undifferentiated malignancies with focal or complete loss of their conventional histomorphologic features. Because tumors with HGT are associated with a worse prognosis than their conventional counterparts, preoperative recognition of HGT may be of benefit for optimal patient management. Using a multi-institutional approach, we describe the largest fine needle aspiration (FNA) cohort of salivary gland carcinomas with HGT. Methods The archives of 9 large academic medical centers were searched, and 22 cases of SGC with HGT were identified by surgical excision accompanied by preoperative FNA. Clinical and cytomorphologic features were retrospectively reviewed. Results The male-to-female ratio was 14:8, and the mean patient age was 60.2 years. The average tumor size was 3.6 cm, and 19 cases were from the parotid gland. Acinic cell carcinoma with HGT was the most common tumor subtype, comprising 12 cases with HGT, followed by adenoid cystic carcinoma, secretory carcinoma, and other subtypes. Eighteen cases were classified as malignant; however, a specific diagnosis of HGT was not made. Sixteen cases contained a high-grade cytologic component, and 7 cases had a mixture of both conventional and high-grade components retrospectively. Conclusions SGC with HGT should be considered in the differential diagnosis of a salivary gland aspirate exhibiting high-grade cytomorphologic features. The presence of distinct tumor populations, conventional and high-grade, should prompt consideration of HGT, especially when the conventional component is acinic cell carcinoma or adenoid cystic carcinoma. |
| تدمد: | 1934-6638 1934-662X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cb13c5887d42fdd82c2f2c29872dc59Test https://doi.org/10.1002/cncy.22388Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....5cb13c5887d42fdd82c2f2c29872dc59 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19346638 1934662X |
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