Lipid peroxidation and antioxidant enzyme activities in patients with type 1 diabetes mellitus
| العنوان: | Lipid peroxidation and antioxidant enzyme activities in patients with type 1 diabetes mellitus |
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| المؤلفون: | Reyes Barberá, Amparo Alegría, María Jesús Lagarda, C. Ruiz, Rosaura Farré |
| المصدر: | ResearcherID |
| بيانات النشر: | Informa UK Limited, 1999. |
| سنة النشر: | 1999 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Erythrocytes, Antioxidant, Thiobarbituric acid, medicine.medical_treatment, Clinical Biochemistry, Thiobarbituric Acid Reactive Substances, Antioxidants, Lipid peroxidation, chemistry.chemical_compound, Internal medicine, Diabetes mellitus, medicine, TBARS, Humans, Triglycerides, Glycated Hemoglobin, chemistry.chemical_classification, Glutathione Peroxidase, Superoxide Dismutase, Cholesterol, Glutathione peroxidase, General Medicine, Middle Aged, medicine.disease, Peroxides, Oxidative Stress, Diabetes Mellitus, Type 1, Endocrinology, chemistry, Metabolic control analysis, Regression Analysis, Female, Lipid Peroxidation |
| الوصف: | To evaluate oxidative stress in type I diabetes mellitus, two antioxidant enzymes in erythrocytes, copper-zinc superoxide dismutase (SOD EC 1.15.1.1.) and seleno-dependent glutathione peroxidase (GSH-Px; EC 1.11.19), and two indexes of peroxidation in plasma, thiobarbituric acid reactive substances (TBARS) and organic hydroperoxides (OHP), were measured in 118 patients with insulin-dependent diabetes mellitus (IDDM), classified in accordance with the presence or absence of vascular complications and the degree of metabolic control established by the HbA1c level. Ninety healthy subjects made up the control group. According to our results, plasmatic TBARS and OHP concentrations are significantly higher in diabetics than in controls, and these differences are accentuated in diabetic people with vascular disorders. The GSH-Px activity was significantly reduced in diabetic patients with poor and medium metabolic control in relation to the control group, regardless of the existence or absence of vascular disorders. No differences in SOD activity between diabetic and control groups were found. A significant positive correlation between TBARS and HPO (r=0.683, p |
| تدمد: | 1502-7686 0036-5513 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c847542485bb473398503416cc78d77Test https://doi.org/10.1080/00365519950185823Test |
| رقم الانضمام: | edsair.doi.dedup.....5c847542485bb473398503416cc78d77 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15027686 00365513 |
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