Contribution and interaction of the low-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and triglyceride to diabetes in hypertensive patients: A cross-sectional study
| العنوان: | Contribution and interaction of the low-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and triglyceride to diabetes in hypertensive patients: A cross-sectional study |
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| المؤلفون: | Ping Gu, Zhiqiang Lu, Yan Ling, Ying Liu, Xin Gao, Jiaqing Shao, Xiaomu Li, Mengyang Hong |
| المصدر: | Journal of Diabetes Investigation, Vol 10, Iss 1, Pp 131-138 (2019) Journal of Diabetes Investigation |
| بيانات النشر: | Wiley, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Male, Lipid abnormality, medicine.medical_specialty, Cross-sectional study, Endocrinology, Diabetes and Metabolism, Low density lipoprotein cholesterol, 030209 endocrinology & metabolism, Type 2 diabetes, 030204 cardiovascular system & hematology, Diseases of the endocrine glands. Clinical endocrinology, Diabetes Complications, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, High-density lipoprotein, Risk Factors, Internal medicine, Diabetes mellitus, Diabetes Mellitus, Internal Medicine, Humans, Medicine, Significant risk, Triglycerides, Triglyceride, business.industry, Cholesterol, Cholesterol, HDL, Diabetes, Articles, Cholesterol, LDL, General Medicine, Middle Aged, RC648-665, medicine.disease, Clinical Science and Care, Cross-Sectional Studies, Endocrinology, chemistry, Hypertension, Original Article, Female, lipids (amino acids, peptides, and proteins), business, Biomarkers |
| الوصف: | Aims/Introduction Hypertension is one of the most significant risk factors for diabetes. The present study aimed to investigate the associations of lipid profiles, including the ratio of low‐density lipoprotein cholesterol (LDL‐C)‐to‐high‐density lipoprotein cholesterol (HDL‐C) and triglyceride (TG) levels, as well as their interactions, with type 2 diabetes in hypertensive patients. Materials and Methods Hypertensive patients without a history of diabetes and hypolipidemic agents were enrolled continuously at the Hypertension Clinic, Zhongshan Hospital, Fudan University (Shanghai, China) from 2014 to 2016. General clinical data, including body mass index, blood pressure, fasting glucose and 2‐h post‐load glucose levels, and lipid profiles, were collected. The LDL‐C/HDL‐C ratio, TG/HDL‐C ratio and TC/HDL‐C ratio were separately calculated. Statistical analyses were carried out by using SPSS software (version 13.0). Results In total, 935 hypertensive patients were included, of which 114 patients (12.2%) were diagnosed with diabetes. After multivariate adjustments, the LDL‐C/HDL‐C ratio and TG levels had the most significant and independent associations with diabetes. In the multivariate logistic regression, the LDL‐C/HDL‐C ratio and TG were independently associated with diabetes. After the interaction variable was included, the LDL‐C/HDL‐C ratio remained independently associated with diabetes, but TG was replaced by TG*LDL‐C/HDL‐C. Conclusions In conclusion, elevated LDL‐C/HDL‐C ratios and TG levels were associated with diabetes in patients with hypertension, with an interactive effect of the LDL‐C/HDL‐C ratio and TG on diabetes in the hypertensive population. |
| تدمد: | 2040-1116 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c0ab9b0b5b15bfd0a4b239464093c1fTest https://doi.org/10.1111/jdi.12856Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....5c0ab9b0b5b15bfd0a4b239464093c1f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20401116 |
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