Differentially Expressed Gene Screening, Biological Function Enrichment, and Correlation with Prognosis in Non-Small Cell Lung Cancer
| العنوان: | Differentially Expressed Gene Screening, Biological Function Enrichment, and Correlation with Prognosis in Non-Small Cell Lung Cancer |
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| المؤلفون: | Qingdong Huang, Liang Gu, Tingyu Tang, Xiaoxi Zhou, Xiaoling Lu, He Huang, Fang Liu |
| المصدر: | Medical Science Monitor : International Medical Journal of Experimental and Clinical Research |
| بيانات النشر: | International Scientific Literature, Inc., 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Lung Neoplasms, MMP1, Peroxisome proliferator-activated receptor, Computational biology, 030204 cardiovascular system & hematology, Biology, 03 medical and health sciences, 0302 clinical medicine, Lab/In Vitro Research, Carcinoma, Non-Small-Cell Lung, Gene expression, Databases, Genetic, Protein Interaction Mapping, Biomarkers, Tumor, Humans, Gene Regulatory Networks, Genetic Predisposition to Disease, Protein Interaction Maps, KEGG, Gene, chemistry.chemical_classification, Regulation of gene expression, Gene Expression Profiling, Computational Biology, General Medicine, Microarray Analysis, Prognosis, Gene Expression Regulation, Neoplastic, Gene Ontology, chemistry, 030220 oncology & carcinogenesis, Actin filament binding, Signal transduction, Transcriptome, Software, Signal Transduction |
| الوصف: | BACKGROUND The aim of this study was to explore the differently expressed genes and pathways in non-small cell lung cancer (NSCLC) and their correlation with the prognosis. MATERIAL AND METHODS Gene expression data series of GSE19804, GSE101929, and GSE33532 were downloaded from the Gene Expression Ominibus (GEO) database. The overlaping differently expressed genes (DEGs) were identified form the above 3 data series. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEEG) were used to analyze the biological functions and signal pathways of DEGs. The protein-protein interaction (PPI) was analyzed thorough Search Tool for the Retrieval of Interacting Gens (STRING). The relationship between the expression of hub genes and the prognosis of patients was analyzed by Kaplan-Meier Plotter online software. RESULTS Twenty-nine DEGs were identified, with 22 upregulated genes and 7 downregulated genes. The enriched biological processes were mainly related to diet-induced thermogenesis and actin filament binding. The KEGG pathways were enriched in calcium signaling, regulation of lipolysis in adipocytes, and PPAR signaling. Two downregulated genes (MMP1 and SPP1) were identified as hub genes by Cytohubba. Twenty-two dysregulated genes were correlated with patient prognosis. CONCLUSIONS Differentially expressed genes are common in NSCLC patients and can be used as biomarkers for patient prognosis. |
| اللغة: | English |
| تدمد: | 1643-3750 1234-1010 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bce19988dededff9b86c2d11a2c050dTest http://europepmc.org/articles/PMC6582684Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....5bce19988dededff9b86c2d11a2c050d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16433750 12341010 |
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