Increasing BMI is associated with reduced expression of P-glycoprotein (ABCB1 gene) in the human brain with a stronger association in African Americans than Caucasians
| العنوان: | Increasing BMI is associated with reduced expression of P-glycoprotein (ABCB1 gene) in the human brain with a stronger association in African Americans than Caucasians |
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| المؤلفون: | Jørgen Rungby, J K Lauridsen, Agnete Larsen, Joel E. Kleinman, Thomas M. Hyde, J Vendelbo, Rasmus H. Olesen |
| المصدر: | The Pharmacogenomics Journal Nielsen, J V, Olesen, R H, Lauridsen, J K, Rungby, J, Kleinmann, J, Hyde, T & Larsen, A 2016, ' Increasing BMI is associated with reduced expression of P-glycoprotein (ABCB1 gene) in the human brain with a stronger association in African-Americans than Caucasians ', The Pharmacogenomics Journal . https://doi.org/10.1038/tpj.2016.74Test |
| بيانات النشر: | Nature Publishing Group, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | 0301 basic medicine, Adult, Male, medicine.medical_specialty, ATP Binding Cassette Transporter, Subfamily B, Adolescent, Pharmacology, Biology, Weight Gain, White People, Body Mass Index, Excretion, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Internal medicine, Genetics, medicine, Humans, ATP Binding Cassette Transporter, Subfamily B, Member 1, Obesity, Polymorphism, Genetic, Microarray analysis techniques, Brain, Human brain, Methylation, DNA Methylation, Middle Aged, medicine.disease, Black or African American, 030104 developmental biology, medicine.anatomical_structure, Endocrinology, Blood-Brain Barrier, DNA methylation, Molecular Medicine, Original Article, Female, medicine.symptom, Weight gain, Body mass index, 030217 neurology & neurosurgery, Antipsychotic Agents |
| الوصف: | The efflux pump, p-glycoprotein, controls bioavailability and excretion of pharmaceutical compounds. In the blood–brain barrier, p-glycoprotein regulates the delivery of pharmaceutical substances to the brain, influencing efficacy and side effects for some drugs notably antipsychotics. Common side effects to antipsychotics include obesity and metabolic disease. Polymorphisms in the ABCB1 gene coding for p-glycoprotein are associated with more severe side effects to neuro-pharmaceuticals as well as weight gain, indicating a potential link between p-glycoprotein function and metabolic regulation. Using microarray data analysis from 145 neurologically sound adults, this study investigated the association between body mass index (BMI) and ABCB1 expression in the frontal cortex. Increasing BMI values were associated with a statistically significantly reduced expression of ABCB1. Investigation of DNA methylation patterns in a subgroup of 52 individuals found that the methylation/expression ratios of ABCB1 were unaffected by increasing BMI values. Interestingly, the effect of BMI on ABCB1 expression appeared stronger in African Americans than in Caucasians. |
| اللغة: | English |
| تدمد: | 1473-1150 1470-269X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b7059200fbf19a4716aa36fa5c7b1caTest http://europepmc.org/articles/PMC5817387Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....5b7059200fbf19a4716aa36fa5c7b1ca |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14731150 1470269X |
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