Outcome of repeat trabeculectomy with mitomycin C in isolation or combined with phacoemulsification
| العنوان: | Outcome of repeat trabeculectomy with mitomycin C in isolation or combined with phacoemulsification |
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| المؤلفون: | Lingam Vijaya, Balekudaru Shantha, Ronnie George, Jeevitha Jagannathan |
| المصدر: | Indian Journal of Ophthalmology Indian Journal of Ophthalmology, Vol 69, Iss 1, Pp 94-98 (2021) |
| بيانات النشر: | Wolters Kluwer - Medknow, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | medicine.medical_specialty, Intraocular pressure, Younger age, Open angle glaucoma, genetic structures, medicine.medical_treatment, Mitomycin, Trabeculectomy, lcsh:Ophthalmology, Ophthalmology, medicine, Phacotrabeculectomy, Humans, success rate, Risk factor, repeat trabeculectomy, Intraocular Pressure, Retrospective Studies, Phacoemulsification, business.industry, Secondary glaucoma, Mitomycin C, eye diseases, Treatment Outcome, risk factor, lcsh:RE1-994, Original Article, sense organs, business, Glaucoma, Open-Angle, Follow-Up Studies |
| الوصف: | Purpose: To evaluate the effectiveness of repeat trabeculectomy with Mitomycin C (MMC) in isolation or combined with phacoemulsification, and to identify risk factors for failure over 1 year. Methods: Retrospective review of 113 eyes of 113 patients (49 primary open angle, 27 primary angle closure, 37 secondary glaucoma) who underwent repeat trabeculectomy with MMC (isolated trabeculectomy 75 and phacotrabeculectomy 38). The primary outcome measure was intraocular pressure (IOP) at 1 year follow-up. Three IOP criteria were chosen to measure success A) IOP ≤21 mmHg and ≥20% reduction from baseline. B) IOP ≤17 mmHg and ≥20% reduction from baseline. C) IOP ≤14 mmHg. Results: Mean IOP decreased from 24.5 ± 8.8 mmHg to 16.4 ± 7.6 mmHg 1 year after repeat trabeculectomy. The mean number of medications reduced from 2.9 ± 1.0 to 0.6 ± 1.0. Complete success with trabeculectomy versus phacotrabeculectomy for criterion A was 60% vs 55.3%, criterion B 54.7% vs 50.0% and criterion C 40.0% vs 28.9%. IOP ≤14 mmHg was more likely with trabeculectomy than phacotrabeculectomy (P = 0.047). On regression analysis, duration between surgeries ≤4 years (P = 0.018) and secondary glaucoma (P = 0.046) were identified as risk factors for surgical failure with criterion A. Younger age (P = 0.042), fornix based flap (P = 0.058), and phacotrabeculectomy (P = 0.042) for criterion C. Conclusion: Repeat trabeculectomy with MMC is successful at lowering IOP and decreasing number of antiglaucoma medications. Low IOP levels are less likely with phacotrabeculectomy. |
| اللغة: | English |
| تدمد: | 1998-3689 0301-4738 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b620f105deba48f22ac9cd7bbd21ac5Test http://europepmc.org/articles/PMC7926097Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....5b620f105deba48f22ac9cd7bbd21ac5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19983689 03014738 |
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