Oxidative Stress: Pathogenetic Role in Diabetes Mellitus and Its Complications and Therapeutic Approaches to Correction
| العنوان: | Oxidative Stress: Pathogenetic Role in Diabetes Mellitus and Its Complications and Therapeutic Approaches to Correction |
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| المؤلفون: | M. A. Darenskaya, Lyubov Kolesnikova, Sergey I. Kolesnikov |
| المصدر: | Bulletin of Experimental Biology and Medicine |
| بيانات النشر: | Springer Science and Business Media LLC, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, Antioxidant, medicine.medical_treatment, Reviews, Inflammation, Context (language use), Disease, Bioinformatics, medicine.disease_cause, patients, General Biochemistry, Genetics and Molecular Biology, Diabetes Complications, Pathogenesis, 03 medical and health sciences, 0302 clinical medicine, Diabetes mellitus, medicine, Animals, Humans, Endothelial dysfunction, experiment, business.industry, General Medicine, medicine.disease, Oxidative Stress, antioxidants, 030104 developmental biology, diabetes mellitus, medicine.symptom, Reactive Oxygen Species, business, 030217 neurology & neurosurgery, Oxidative stress |
| الوصف: | The review presents modern views about the role of oxidative stress reactions in the pathogenesis of types 1 and 2 diabetes mellitus and their complications based on the analysis of experimental and clinical studies. The sources of increased ROS generation in diabetes are specified, including the main pathways of altered glucose metabolism, oxidative damage to pancreatic β-cells, and endothelial dysfunction. The relationship between oxidative stress, carbonyl stress, and inflammation is described. The significance of oxidative stress reactions associated with hyperglycemia is considered in the context of the "metabolic memory" phenomenon. The results of our studies demonstrated significant ethnic and age-related variability of the LPO-antioxidant defense system parameters in patients with diabetes mellitus, which should be considered during complex therapy of the disease. Numerous studies of the effectiveness of antioxidants in diabetes mellitus of both types convincingly proved that antioxidants should be a part of the therapeutic process. Modern therapeutic strategies in the treatment of diabetes mellitus are aimed at developing new methods of personalized antioxidant therapy, including ROS sources targeting combined with new ways of antioxidant delivery. |
| تدمد: | 1573-8221 0007-4888 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b5e17b6d53dfbee9935ac20a5e510b8Test https://doi.org/10.1007/s10517-021-05191-7Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....5b5e17b6d53dfbee9935ac20a5e510b8 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15738221 00074888 |
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