CD4+ T-Cell Plasticity in Non-Infectious Retinal Inflammatory Disease
| العنوان: | CD4+ T-Cell Plasticity in Non-Infectious Retinal Inflammatory Disease |
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| المؤلفون: | Susan Lightman, Virginia L. Calder, Yi-Hsing Chen |
| المصدر: | International Journal of Molecular Sciences, Vol 22, Iss 9584, p 9584 (2021) |
| بيانات النشر: | MDPI AG, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Adoptive cell transfer, experimental autoimmune uveitis, QH301-705.5, chemical and pharmacologic phenomena, Disease, Biology, Catalysis, Inorganic Chemistry, chemistry.chemical_compound, Th1 cells, medicine, IL-2 receptor, Physical and Theoretical Chemistry, Th17 cells, Biology (General), Molecular Biology, QD1-999, Spectroscopy, Th17/Th1 (CD4+IFNγ+IL-17+) cells, Effector, Th17/Treg (CD4+IL-17+FoxP3+) cells, Organic Chemistry, FOXP3, Retinal, hemic and immune systems, General Medicine, medicine.disease, Phenotype, Computer Science Applications, regulatory (Treg) T cells, Chemistry, chemistry, Immunology, Uveitis |
| الوصف: | Non-infectious uveitis (NIU) is a potentially sight-threatening disease. Effector CD4+ T cells, especially interferon-γ-(IFNγ) producing Th1 cells and interleukin-17-(IL-17) producing Th17 cells, are the major immunopathogenic cells, as demonstrated by adoptive transfer of disease in a model of experimental autoimmune uveitis (EAU). CD4+FoxP3+CD25+ regulatory T cells (Tregs) were known to suppress function of effector CD4+ T cells and contribute to resolution of disease. It has been recently reported that some CD4+ T-cell subsets demonstrate shared phenotypes with another CD4+ T-cell subset, offering the potential for dual function. For example, Th17/Th1 (co-expressing IFNγ and IL-17) cells and Th17/Treg (co-expressing IL-17 and FoxP3) cells have been identified in NIU and EAU. In this review, we have investigated the evidence as to whether these ‘plastic CD4+ T cells’ are functionally active in uveitis. We conclude that Th17/Th1 cells are generated locally, are resistant to the immunosuppressive effects of steroids, and contribute to early development of EAU. Th17/Treg cells produce IL-17, not IL-10, and act similar to Th17 cells. These cells were considered pathogenic in uveitis. Future studies are needed to better clarify their function, and in the future, these cell subsets may in need to be taken into consideration for designing treatment strategies for disease. |
| اللغة: | English |
| تدمد: | 1661-6596 1422-0067 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b5343fa20751245e863e2a1894a82c8Test https://www.mdpi.com/1422-0067/22/17/9584Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....5b5343fa20751245e863e2a1894a82c8 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16616596 14220067 |
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