An IGF-I gene polymorphism modifies the risk of developing persistent microalbuminuria in type 1 diabetes
| العنوان: | An IGF-I gene polymorphism modifies the risk of developing persistent microalbuminuria in type 1 diabetes |
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| المؤلفون: | Lise Tarnow, Peter Hovind, Steven W. J. Lamberts, Jaap Deinum, Wim C. J. Hop, Hans-Henrik Parving, Joop A. M. J. L. Janssen |
| المساهمون: | Internal Medicine, Epidemiology |
| المصدر: | European Journal of Endocrinology, 156, 83-90 European Journal of Endocrinology, 156, 1, pp. 83-90 European Journal of Endocrinology, 156(1), 83-90. Bioscientifica Ltd |
| بيانات النشر: | Oxford University Press (OUP), 2007. |
| سنة النشر: | 2007 |
| مصطلحات موضوعية: | Adult, Male, Risk, medicine.medical_specialty, Adolescent, Genotype, Endocrinology, Diabetes and Metabolism, Blood Pressure, Vascular medicine and diabetes [UMCN 2.2], Diabetes Complications, Endocrinology, Gene Frequency, SDG 3 - Good Health and Well-being, Internal medicine, Albuminuria, Humans, Medicine, Insulin-Like Growth Factor I, Child, Promoter Regions, Genetic, Alleles, Type 1 diabetes, Polymorphism, Genetic, Proteinuria, Cardiovascular diseases [NCEBP 14], C-Peptide, business.industry, Variant type, Wild type, Infant, DNA, General Medicine, medicine.disease, Diabetes Mellitus, Type 1, Child, Preschool, Cohort, Female, Microalbuminuria, Gene polymorphism, medicine.symptom, business |
| الوصف: | Objective: Derangements of the GH–IGF-I axis have been associated with microalbuminuria (MA) in type 1 diabetes. The aim of this study was to investigate whether anIGF-Igene promoter polymorphism influenced the development of persistent MA in type 1 diabetes.Design: A prospective follow-up study of a cohort of 277 patients with newly diagnosed type 1 diabetes consecutively enrolled between September 1979 and August 1984.Methods: Urinary albumin excretion rate over 24 h was measured in each patient at least once a year. Persistent MA was defined as a urinary albumin excretion rate between 30 and 300 mg/24 h.Results: During a median follow-up of 18.0 years (range 1.0–21.5), 79 of 277 patients developed persistent MA.IGF-Igene genotype was available for 216 subjects; in 73% of the subjects, the wild-type genotype of this IGF-I gene polymorphism was present, while 27% had the variant type. At baseline, there were no differences in IGF-I levels and HbA1cvalues between subjects with the wild type and subjects with variant type. By Kaplan–Meier analysis, subjects with the variant type of this polymorphism had during follow-up a higher risk of development of MA compared subjects with the wild type (P= 0.03).Conclusions: Subjects with the variant type of anIGF-Igene polymorphism had a significantly increased risk of developing MA. This risk was not mediated through changes in circulating IGF-I levels. Our study suggests that in type 1 diabetes, thisIGF-Igene polymorphism is a risk factor of MA. |
| وصف الملف: | application/pdf |
| تدمد: | 1479-683X 0804-4643 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b1602d735d9d572e62f5d1cc3cd9012Test https://doi.org/10.1530/eje.1.02308Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....5b1602d735d9d572e62f5d1cc3cd9012 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1479683X 08044643 |
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