Involvement of virus-induced interferon production in IgG autoantibody-mediated anemia
| العنوان: | Involvement of virus-induced interferon production in IgG autoantibody-mediated anemia |
|---|---|
| المؤلفون: | Shozo Izui, Dan Su, Cor Breukel, J. Sjef Verbeek, Jill W. C. Claassens, Mélanie Gaignage, Conny Brouwers, Jean-Paul Coutelier, Margot M. Linssen, Sarah Legrain |
| المصدر: | International Journal of Molecular Sciences, 22(16). MDPI International Journal of Molecular Sciences Volume 22 Issue 16 International Journal of Molecular Sciences, Vol 22, Iss 9027, p 9027 (2021) |
| بيانات النشر: | MDPI, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | QH301-705.5, Anemia, Phagocytosis, Article, Catalysis, Virus, Inorganic Chemistry, Interferon, medicine, Animals, IgG Autoantibody, autoimmune anemia, Biology (General), Physical and Theoretical Chemistry, Receptor, QD1-999, Molecular Biology, Spectroscopy, Mice, Knockout, Arterivirus Infections, biology, Chemistry, Fc receptors, Receptors, IgG, Organic Chemistry, lactate dehydrogenase-elevating virus, General Medicine, interferon, biology.organism_classification, medicine.disease, Computer Science Applications, Mice, Inbred C57BL, Interferon production, Host-Pathogen Interactions, Immunology, Anemia, Hemolytic, Autoimmune, Interferons, Lactate dehydrogenase elevating virus, medicine.drug |
| الوصف: | Infection with viruses, such as the lactate dehydrogenase-elevating virus (LDV), is known to trigger the onset of autoimmune anemia through the enhancement of the phagocytosis of autoantibody-opsonized erythrocytes by activated macrophages. Type I interferon receptor-deficient mice show enhanced anemia, which suggests a protective effect of these cytokines, partly through the control of type II interferon production. The development of anemia requires the expression of Fc gamma receptors (Fc gamma R) I, III, and IV. Whereas LDV infection decreases Fc gamma R III expression, it enhances Fc gamma R I and IV expression in wild-type animals. The LDV-associated increase in the expression of Fc gamma R I and IV is largely reduced in type I interferon receptor-deficient mice, through both type II interferon-dependent and -independent mechanisms. Thus, the regulation of the expression of Fc gamma R I and IV, but not III, by interferons may partly explain the exacerbating effect of LDV infection on anemia that results from the enhanced phagocytosis of IgG autoantibody-opsonized erythrocytes. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5aebe3f03de742beeb5288e00b271c01Test https://hdl.handle.net/1887/3213013Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....5aebe3f03de742beeb5288e00b271c01 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |