Pentraxin 3 (PTX3) is associated with cardiovascular risk factors: the Health 2000 Survey
| العنوان: | Pentraxin 3 (PTX3) is associated with cardiovascular risk factors: the Health 2000 Survey |
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| المؤلفون: | Atte Haarala, Leena Moilanen, Mika Kähönen, Markku S. Nieminen, Y. A. Kesäniemi, Mikko Hurme, Antti Jula, Terho Lehtimäki, Juulia Jylhävä |
| المصدر: | Clinical and Experimental Immunology. 164:211-217 |
| بيانات النشر: | Oxford University Press (OUP), 2011. |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Translational Studies, Hypercholesterolemia, Immunology, Cardiovascular risk factors, Blood Pressure, Disease, Pathogenesis, chemistry.chemical_compound, Risk Factors, Internal medicine, medicine, Humans, Indoleamine-Pyrrole 2,3,-Dioxygenase, Immunology and Allergy, Finland, Aged, Ultrasonography, Anthropometry, business.industry, Cholesterol, Age Factors, PTX3, Middle Aged, Pulse pressure, Serum Amyloid P-Component, C-Reactive Protein, Carotid Arteries, Cross-Sectional Studies, Endocrinology, Blood pressure, chemistry, Cardiovascular Diseases, Hypertension, Female, Insulin Resistance, business, Biomarkers, Lipoprotein |
| الوصف: | Summary Pentraxin 3 (PTX3) is a novel candidate immunoinflammatory marker that has been reported to be associated with cardiometabolic risk factors and to predict adverse outcomes in individuals with cardiovascular disease (CVD). Despite being a member of the same pentraxin protein family as C-reactive protein (CRP), PTX3 probably reflects different aspects of CVD pathogenesis. In this study, we assessed plasma PTX3 correlates and determinants in the Health 2000 Survey population, which comprised n = 403 insulin-resistant subjects, n = 845 hypercholesterolaemic subjects and n = 311 hypertensive subjects, all aged between 46 and 76 years. In insulin-resistant subjects the PTX3 concentration was found to correlate directly with age, pulse pressure and indoleamine 2,3-dioxygenase (IDO) enzyme activity and inversely with total and low-density lipoprotein (LDL) cholesterol. In hypercholesterolaemic subjects, the PTX3 concentration correlated directly with HDL cholesterol, systolic blood pressure and pulse pressure, whereas in hypertensive subjects, the PTX3 concentration correlated directly with systolic blood pressure, pulse pressure and IDO activity. No correlation was observed between the concentrations of PTX3 and CRP, adiposity indicators or indicators of subclinical atherosclerosis in any of the subject groups. PTX3 concentration variations were attributed to variations in LDL cholesterol and IDO activity in insulin-resistant subjects and to pulse pressure in hypercholesterolaemic and hypertensive subjects. These results indicate that, in individuals at high risk of CVD, the PTX3 concentration is associated with cardiovascular risk factors but not with subclinical atherosclerosis. |
| تدمد: | 1365-2249 0009-9104 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5abf5b69fec941fcb75ea2e5433e9be6Test https://doi.org/10.1111/j.1365-2249.2011.04354.xTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....5abf5b69fec941fcb75ea2e5433e9be6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13652249 00099104 |
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