Lipoprotein Subfraction Cholesterol Distribution Is Proatherogenic in Women With Type 1 Diabetes and Insulin Resistance
| العنوان: | Lipoprotein Subfraction Cholesterol Distribution Is Proatherogenic in Women With Type 1 Diabetes and Insulin Resistance |
|---|---|
| المؤلفون: | Hong Tian Wang, David M. Maahs, Gregory L. Kinney, Robert H. Eckel, John E. Hokanson, Bryan C. Bergman, Irene E. Schauer, Janet K. Snell-Bergeon, Ashley East, Marian Rewers |
| المصدر: | Diabetes |
| بيانات النشر: | American Diabetes Association, 2010. |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Very low-density lipoprotein, Endocrinology, Diabetes and Metabolism, Lipoproteins, 030209 endocrinology & metabolism, 030204 cardiovascular system & hematology, Biology, Intra-Abdominal Fat, Pathophysiology, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Insulin resistance, Sex Factors, Internal medicine, Diabetes mellitus, Internal Medicine, medicine, Humans, Type 1 diabetes, Chi-Square Distribution, Cholesterol, Patient Selection, Glucose clamp technique, Middle Aged, medicine.disease, 3. Good health, Endocrinology, Diabetes Mellitus, Type 1, chemistry, Cardiovascular Diseases, Glucose Clamp Technique, lipids (amino acids, peptides, and proteins), Female, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Insulin Resistance, Chi-squared distribution, Lipoprotein, Chromatography, Liquid |
| الوصف: | OBJECTIVEIndividuals with type 1 diabetes have a less atherogenic fasting lipid profile than those without diabetes but paradoxically have increased rates of cardiovascular disease (CVD). We investigated differences in lipoprotein subfraction cholesterol distribution and insulin resistance between subjects with and without type 1 diabetes to better understand the etiology of increased CVD risk.RESEARCH DESIGN AND METHODSFast protein liquid chromatography was used to fractionate lipoprotein cholesterol distribution in a substudy of the Coronary Artery Calcification in Type 1 Diabetes (CACTI) study (n = 82, age 46 ± 8 years, 52% female, 49% with type 1 diabetes for 23 ± 8 years). Insulin resistance was assessed by a hyperinsulinemic-euglycemic clamp.RESULTSAmong men, those with type 1 diabetes had less VLDL and more HDL cholesterol than control subjects (P < 0.05), but among women, those with diabetes had a shift in cholesterol to denser LDL, despite more statin use. Among control subjects, men had more cholesterol distributed as VLDL and LDL but less as HDL than women; however, among those with type 1 diabetes, there was no sex difference. Within sex and diabetes strata, a more atherogenic cholesterol distribution by insulin resistance was seen in men with and without diabetes, but only in women with type 1 diabetes.CONCLUSIONSThe expected sex-based less atherogenic lipoprotein cholesterol distribution was not seen in women with type 1 diabetes. Moreover, insulin resistance was associated with a more atherogenic lipoprotein cholesterol distribution in all men and in women with type 1 diabetes. This lipoprotein cholesterol distribution may contribute to sex-based differences in CVD in type 1 diabetes. |
| اللغة: | English |
| تدمد: | 1939-327X 0012-1797 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5aa71a7d05aa50cff9a91b451754e134Test http://europepmc.org/articles/PMC2889778Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....5aa71a7d05aa50cff9a91b451754e134 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1939327X 00121797 |
|---|