Normal limits for oscillometric bronchodilator responses and relationships with clinical factors
| العنوان: | Normal limits for oscillometric bronchodilator responses and relationships with clinical factors |
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| المؤلفون: | Guy B. Marks, David P Johns, Nathan J. Brown, Claude S. Farah, Chantale Boustany, Michael J. Abramson, Michael Hunter, Norbert Berend, Alan L. James, David G. Chapman, Arthur W. Musk, Cindy Thamrin, Gregory G King, Brett G. Toelle, Kanika Jetmalani |
| المصدر: | ERJ Open Research, Vol 7, Iss 4 (2021) ERJ Open Research article-version (VoR) Version of Record |
| بيانات النشر: | European Respiratory Society, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Pulmonary and Respiratory Medicine, Spirometry, medicine.medical_specialty, COPD, Percentile, Inhalation, medicine.diagnostic_test, business.industry, medicine.drug_class, medicine.disease, Lung Function, Internal medicine, Bronchodilator, Original Research Articles, medicine, Salbutamol, Oscillometry, Medicine, business, Asthma, medicine.drug |
| الوصف: | Introduction We aimed to determine normal thresholds for positive bronchodilator responses for oscillometry in an Australian general population sample aged ≥40 years, to guide clinical interpretation. We also examined relationships between bronchodilator responses and respiratory symptoms, asthma diagnosis, smoking and baseline lung function. Methods Subjects recruited from Sydney, Melbourne and Busselton, Australia, underwent measurements of spirometry, resistance (Rrs6) and reactance (Xrs6) at 6 Hz, before and after inhalation of salbutamol 200 μg. Respiratory symptoms and/or medication use, asthma diagnosis, and smoking were recorded. Threshold bronchodilator responses were defined as the fifth percentile of decrease in Rrs6 and 95th percentile increase in Xrs6 in a healthy subgroup. Results Of 1318 participants, 1145 (570 female) were analysed. The lower threshold for ΔRrs6 was −1.38 cmH2O·s·L−1 (−30.0% or −1.42 Z-scores) and upper threshold for ΔXrs6 was 0.57 cmH2O·s·L−1 (1.36 Z-scores). Respiratory symptoms and/or medication use, asthma diagnosis, and smoking all predicted bronchodilator response, as did baseline oscillometry and spirometry. When categorised into clinically relevant groups according to those predictors, ΔXrs6 was more sensitive than spirometry in smokers without current asthma or chronic obstructive pulmonary disease (COPD), ∼20% having a positive response. Using absolute or Z-score change provided similar prevalences of responsiveness, except in COPD, in which responsiveness measured by absolute change was twice that for Z-score. Discussion This study describes normative thresholds for bronchodilator responses in oscillometry parameters, including intra-breath parameters, as determined by absolute, relative and Z-score changes. Positive bronchodilator response by oscillometry correlated with clinical factors and baseline function, which may inform the clinical interpretation of oscillometry. Normative values for bronchodilator responses measured by oscillometry were derived. Responsiveness related to clinical factors and baseline function. Reactance was more sensitive in detecting bronchodilator response than spirometry mild airways disease. https://bit.ly/3wtWVeVTest |
| وصف الملف: | Electronic-eCollection; application/pdf |
| اللغة: | English |
| تدمد: | 2312-0541 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59f2c7c9f9b22176079fa9e14d5ecf83Test http://openres.ersjournals.com/content/7/4/00439-2021.fullTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....59f2c7c9f9b22176079fa9e14d5ecf83 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 23120541 |
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