Soluble CD8 antigen, stimulated C-peptide and islet cell antibodies are predictors of insulin requirement in newly diagnosed patients with unclassifiable diabetes
| العنوان: | Soluble CD8 antigen, stimulated C-peptide and islet cell antibodies are predictors of insulin requirement in newly diagnosed patients with unclassifiable diabetes |
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| المؤلفون: | P. Di Bonito, Antonio Bizzarro, A. De Bellis, E. Pace, S. Turco, Brunella Capaldo, G. Corigliano |
| المساهمون: | DI BONITO, P, DE BELLIS, Annamaria, Capaldo, B, Turco, S, Corigliano, C, Pace, E, Bizzarro, Antonio, DE BELLIS, A, Capaldo, Brunella, Corigliano, G, Bizzarro, A. |
| المصدر: | Acta Diabetologica. 33:220-224 |
| بيانات النشر: | Springer Science and Business Media LLC, 1996. |
| سنة النشر: | 1996 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Adolescent, CD8 Antigens, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Body Mass Index, Islets of Langerhans, Basal (phylogenetics), chemistry.chemical_compound, HLA-DR3 Antigen, Endocrinology, Antigen, Antigens, CD, Predictive Value of Tests, Internal medicine, Diabetes mellitus, Diabetes Mellitus, Internal Medicine, Humans, Insulin, Medicine, Prospective Studies, Child, Autoantibodies, Glycated Hemoglobin, geography, geography.geographical_feature_category, C-Peptide, biology, business.industry, C-peptide, Histocompatibility Testing, Autoantibody, General Medicine, Glucose Tolerance Test, Glucagon, Islet, medicine.disease, Diabetes Mellitus, Type 1, chemistry, biology.protein, Female, Antibody, business, Biomarkers |
| الوصف: | To evaluate the predictive factors of insulin requirement in newly diagnosed patients with unclassifiable diabetes, 54 consecutive patients, aged less than 35 years, were prospectively followed for 3 years or more. At entry, haemoglobin HbA1c, basal and stimulated C-peptide concentrations, HLA phenotype, islet cell antibodies (ICA) status, and serum levels of soluble CD8 antigen (sCD8) were evaluated. After a median time of 9 (range 2-32) months, 31 patients (group 1) required insulin therapy, whereas 23 patients (group 2) remained non-insulin-requiring after 36 months. Group 1 patients were younger (P0.05) and had higher HbA1c and sCD8 serum levels (P0.0001), respectively), a higher frequency of ICA positivity and of HLA DR3 and/or DR4 phenotype (P0.005 and P0.0001, respectively), and lower C-peptide concentrations (P0.005 and P0.0001, basal and stimulated, respectively) than group 2. The sensitivity, specificity, positive and negative predictive value, and overall accuracy for the subsequent insulin requirement were: sCD8 serum levels (737 U/ml), 100%, 65%, 79%, 100% and 85%, respectively; stimulated C-peptide (0.60 nmol/l), 71%, 96%, 96%, 74% and 81%, respectively; and ICA positivity (20 JDFU), 45%, 91%, 87%, 55% and 65%, respectively. Thus, higher sCD8 serum levels, low stimulated C-peptide concentrations and ICA positivity are the most powerful predictors of subsequent recourse to insulin therapy in young, newly detected patients with unclassifiable diabetes. |
| تدمد: | 1432-5233 0940-5429 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59bc5edc9df2727057fe56bc3867cf3dTest https://doi.org/10.1007/bf02048547Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....59bc5edc9df2727057fe56bc3867cf3d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14325233 09405429 |
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