Cephalometric oropharynx and oral cavity analysis in Chiari malformation Type I: a retrospective case-control study
| العنوان: | Cephalometric oropharynx and oral cavity analysis in Chiari malformation Type I: a retrospective case-control study |
|---|---|
| المؤلفون: | M.A. Poca, Alex Rovira, Alex Ferré, Juan Sahuquillo, Bryn A. Martin, Aintzane Urbizu, Alfons Macaya |
| المصدر: | Journal of Neurosurgery. 126:626-633 |
| بيانات النشر: | Journal of Neurosurgery Publishing Group (JNSPG), 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Cephalometry, Oropharynx, Young Adult, 03 medical and health sciences, 0302 clinical medicine, medicine, Humans, 030223 otorhinolaryngology, Aged, Mouth, Foramen magnum, medicine.diagnostic_test, Soft palate, business.industry, Occipital bone, Magnetic resonance imaging, Sensory loss, General Medicine, Middle Aged, Magnetic Resonance Imaging, Dysphagia, Arnold-Chiari Malformation, Surgery, medicine.anatomical_structure, Posterior cranial fossa, Case-Control Studies, Female, medicine.symptom, Headaches, business, 030217 neurology & neurosurgery |
| الوصف: | OBJECTIVETraditionally, Chiari malformation Type I has been related to downward herniation of the cerebellar tonsils as a consequence of an underdeveloped posterior cranial fossa. Although the common symptoms of Chiari malformation Type I are occipital headaches, cervical pain, dizziness, paresthesia, and sensory loss, patients often report symptoms related to pharyngeal dysfunction such as choking, regurgitation, dysphagia, aspiration, chronic cough, and sleep disorders. In addition, tracheal intubation is often difficult in these patients. The purpose of this study was to analyze the morphological features of the oropharynx and oral cavity in patients with Chiari malformation Type I to help identify underlying anatomical anomalies leading to these debilitating symptoms.METHODSSeventy-six adult patients with symptomatic Chiari malformation Type I with cerebellar tonsillar descent greater than 5 mm below the foramen magnum and a small posterior cranial fossa and 49 sex-matched controls were selected to perform a retrospective case-control MRI-based morphometric study in a tertiary hospital. Eleven linear and areal parameters of the oropharyngeal cavity on midsagittal T1-weighted MRI were measured and the average values between patients and control cohorts were compared. Correlations between variables showing or approaching statistical significance in these structures and posterior cranial fossa measurements related with the occipital bone were sought.RESULTSSignificant differences were detected for several oropharynx and oral cavity measures in the patient cohort, primarily involving the length and thickness of the soft palate (p = 9.5E-05 and p = 3.0E-03, respectively). A statistically significant (p < 0.01) moderate correlation between some of these variables and posterior cranial fossa parameters was observed.CONCLUSIONSThe existence of structural oropharyngeal and oral cavity anomalies in patients with Chiari malformation Type I was confirmed, which may contribute to the frequent occurrence of respiratory and deglutitory complications and sleep disorders in this syndrome. |
| تدمد: | 1933-0693 0022-3085 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59ab7ee27e75ab5710e63d13f04ee01cTest https://doi.org/10.3171/2016.1.jns151590Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....59ab7ee27e75ab5710e63d13f04ee01c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19330693 00223085 |
|---|