Pushing Past the Blockade: Advancements in T Cell-Based Cancer Immunotherapies
| العنوان: | Pushing Past the Blockade: Advancements in T Cell-Based Cancer Immunotherapies |
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| المؤلفون: | Emily Lerner, Alexandra Hoyt-Miggelbrink, Peter E. Fecci, Jessica Waibl Polania, Daniel Wilkinson |
| المصدر: | Frontiers in Immunology, Vol 12 (2021) Frontiers in Immunology |
| بيانات النشر: | Frontiers Media S.A., 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | CAR (chimeric antigen receptor) T cells, medicine.medical_treatment, T cell, T-Lymphocytes, Immunology, immune checkpoint inhibition (ICI), Review, immunotherapy resistance, Immune system, Lymphocytes, Tumor-Infiltrating, Neoplasms, Tumor-Associated Macrophages, Biomarkers, Tumor, Immunology and Allergy, Medicine, Cytotoxic T cell, Animals, Humans, tumor microenvironment, Tumor microenvironment, business.industry, tumor-associated macrophage (TAM), Immunity, Cancer, Disease Management, Immunotherapy, RC581-607, medicine.disease, Prognosis, Combined Modality Therapy, Chimeric antigen receptor, Immune checkpoint, medicine.anatomical_structure, Treatment Outcome, Cancer research, Disease Susceptibility, immunotherapy, Immunologic diseases. Allergy, business |
| الوصف: | Successful cancer immunotherapies rely on a replete and functional immune compartment. Within the immune compartment, T cells are often the effector arm of immune-based strategies due to their potent cytotoxic capabilities. However, many tumors have evolved a variety of mechanisms to evade T cell-mediated killing. Thus, while many T cell-based immunotherapies, such as immune checkpoint inhibition (ICI) and chimeric antigen receptor (CAR) T cells, have achieved considerable success in some solid cancers and hematological malignancies, these therapies often fail in solid tumors due to tumor-imposed T cell dysfunctions. These dysfunctional mechanisms broadly include reduced T cell access into and identification of tumors, as well as an overall immunosuppressive tumor microenvironment that elicits T cell exhaustion. Therefore, novel, rational approaches are necessary to overcome the barriers to T cell function elicited by solid tumors. In this review, we will provide an overview of conventional immunotherapeutic strategies and the various barriers to T cell anti-tumor function encountered in solid tumors that lead to resistance. We will also explore a sampling of emerging strategies specifically aimed to bypass these tumor-imposed boundaries to T cell-based immunotherapies. |
| اللغة: | English |
| تدمد: | 1664-3224 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::598ff21f4d78a1834e84aa783be58e21Test https://www.frontiersin.org/articles/10.3389/fimmu.2021.777073/fullTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....598ff21f4d78a1834e84aa783be58e21 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16643224 |
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