Effects of Ginsenosides on Organogenesis and Expression of Glutathione Peroxidase Genes in Cultured Rat Embryos
| العنوان: | Effects of Ginsenosides on Organogenesis and Expression of Glutathione Peroxidase Genes in Cultured Rat Embryos |
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| المؤلفون: | Sang-Yoon Nam, Gyeung-Haeng Hur, Young-Won Yun, Beom-Jun Lee, Yun-Bae Kim, Jung-Min Yon, Byeongwoo Ahn, In-Jeoung Baek, Rhee-Da Lee, Mi-Ra Kim, Soon-Sun Kim, Dae-Hyun Cho, Se-Ra Lee, Seung-Jun Kwack |
| المصدر: | Journal of Reproduction and Development. 54:164-170 |
| بيانات النشر: | Japanese Society of Animal Reproduction, 2008. |
| سنة النشر: | 2008 |
| مصطلحات موضوعية: | animal structures, Ginsenosides, Organogenesis, Antioxidants, Gene Expression Regulation, Enzymologic, Embryo Culture Techniques, Andrology, chemistry.chemical_compound, Ginseng, Pregnancy, Gene expression, Animals, chemistry.chemical_classification, Glutathione Peroxidase, Dose-Response Relationship, Drug, biology, Reverse Transcriptase Polymerase Chain Reaction, Glutathione peroxidase, Gene Expression Regulation, Developmental, Embryo, Glutathione, Molecular biology, Rats, chemistry, Ginsenoside, biology.protein, Female, Animal Science and Zoology, Peroxidase |
| الوصف: | Ginseng has been extensively used around the world for several thousand years as a food or drug. However, recently, several reports have indicated that the organogenesis of cultured embryos is inhibited by treatment with ginsenoside, the principal component of ginseng. In this study, we evaluated the morphological changes of embryos and the gene expression patterns of antioxidant enzymes, 3 types of glutathione peroxidases [GPx; cytosolic (cGPx), plasma (pGPx) and phospholipid hydroperoxide (phGPx) forms], in cultured rat embryos (embryonic days 9.5-11.5) exposed to ginsenosides Rb1, Rg1, Re and Rc at levels of 5, 50 and 100 microg/ml. With regard to total morphological scores, no significant differences were noted in the embryos exposed to all doses of ginsenosides, with the exception of 50 microg/ml of Rc. In the cultured embryos exposed to Rg1, a majority of the developmental parameters were normal, but growth of the hind- and mid- brains and the caudal neural tube was significantly increased compared with that observed in the control group (P |
| تدمد: | 1348-4400 0916-8818 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58110d6ae08ac3bd53f36b71cc4eb282Test https://doi.org/10.1262/jrd.19152Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....58110d6ae08ac3bd53f36b71cc4eb282 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13484400 09168818 |
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