The Use of a Smart Bolus Calculator Informed by Real-time Insulin Sensitivity Assessments Reduces Postprandial Hypoglycemia Following an Aerobic Exercise Session in Individuals With Type 1 Diabetes
| العنوان: | The Use of a Smart Bolus Calculator Informed by Real-time Insulin Sensitivity Assessments Reduces Postprandial Hypoglycemia Following an Aerobic Exercise Session in Individuals With Type 1 Diabetes |
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| المؤلفون: | Mary C. Oliveri, Marc D. Breton, Stacey M. Anderson, Charlotte L. Barnett, Kelly Carr, Daniel R. Cherñavvsky, Ralf Nass, Jennifer Pinnata, Chaitanya L.K. Koravi, Chiara Fabris |
| المصدر: | Diabetes Care |
| بيانات النشر: | American Diabetes Association, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Adult, Blood Glucose, Male, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, 030209 endocrinology & metabolism, Hypoglycemia, Young Adult, 03 medical and health sciences, Insulin Infusion Systems, 0302 clinical medicine, Bolus (medicine), Emerging Technologies: Data Systems and Devices, Diabetes mellitus, Internal Medicine, medicine, Humans, Hypoglycemic Agents, Insulin, Aerobic exercise, Drug Dosage Calculations, 030212 general & internal medicine, Dosing, Exercise, Meals, Advanced and Specialized Nursing, Type 1 diabetes, business.industry, Blood Glucose Self-Monitoring, Equipment Design, Middle Aged, Postprandial Period, medicine.disease, Diabetes Mellitus, Type 1, Hyperglycemia, Anesthesia, Female, Insulin Resistance, business, Postprandial Hypoglycemia |
| الوصف: | OBJECTIVE Insulin dosing in type 1 diabetes (T1D) is oftentimes complicated by fluctuating insulin requirements driven by metabolic and psychobehavioral factors impacting individuals’ insulin sensitivity (IS). In this context, smart bolus calculators that automatically tailor prandial insulin dosing to the metabolic state of a person can improve glucose management in T1D. RESEARCH DESIGN AND METHODS Fifteen adults with T1D using continuous glucose monitors (CGMs) and insulin pumps completed two 24-h admissions in a hotel setting. During the admissions, participants engaged in an early afternoon 45-min aerobic exercise session, after which they received a standardized dinner meal. The dinner bolus was computed using a standard bolus calculator or smart bolus calculator informed by real-time IS estimates. Glucose control was assessed in the 4 h following dinner using CGMs and was compared between the two admissions. RESULTS The IS-informed bolus calculator allowed for a reduction in postprandial hypoglycemia as quantified by the low blood glucose index (2.02 vs. 3.31, P = 0.006) and percent time 180 mg/dL: 13.24% vs. 10.42%, P = 0.5; percent time >250 mg/dL: 2.08% vs. 1.19%, P = 0.317). In addition, the number of hypoglycemia rescue treatments was reduced from 12 to 7 with the use of the system. CONCLUSIONS The study shows that the proposed IS-informed bolus calculator is safe and feasible in adults with T1D, appropriately reducing postprandial hypoglycemia following an exercise-induced IS increase. |
| تدمد: | 1935-5548 0149-5992 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57f95a83bba9097b721755c1f1e9a065Test https://doi.org/10.2337/dc19-1675Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....57f95a83bba9097b721755c1f1e9a065 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19355548 01495992 |
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