Pharmacokinetic-pharmacodynamic integration and modelling of oxytetracycline for the calf pathogens Mannheimia haemolytica and Pasteurella multocida
| العنوان: | Pharmacokinetic-pharmacodynamic integration and modelling of oxytetracycline for the calf pathogens Mannheimia haemolytica and Pasteurella multocida |
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| المؤلفون: | Ludovic Pelligand, Pierre-Louis Toutain, T J Potter, Peter Lees |
| المساهمون: | Royal Veterinary College, ToxAlim (ToxAlim), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole d'Ingénieurs de Purpan (INPT - EI Purpan), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Recherche Agronomique (INRA), Department for the Environment, Food and Rural Affairs (United Kingdom) |
| المصدر: | Journal of Veterinary Pharmacology and Therapeutics Journal of Veterinary Pharmacology and Therapeutics, Wiley-Blackwell, 2017, ⟨10.1111/jvp.12439⟩ JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS Journal of Veterinary Pharmacology and Therapeutics, Wiley-Blackwell, 2017, 41 (1), ⟨10.1111/jvp.12439⟩ |
| بيانات النشر: | HAL CCSD, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, Pasteurella multocida, 040301 veterinary sciences, animal diseases, [SDV]Life Sciences [q-bio], 030106 microbiology, Pasteurella Infections, Cmax, Oxytetracycline, Microbial Sensitivity Tests, Pharmacology, Injections, Intramuscular, Microbiology, 0403 veterinary science, 03 medical and health sciences, Minimum inhibitory concentration, Blood serum, Pharmacokinetics, medicine, Animals, Mannheimia haemolytica, Minimum bactericidal concentration, General Veterinary, biology, 04 agricultural and veterinary sciences, biology.organism_classification, Bacterial Load, Pneumonia of Calves, Enzootic, Anti-Bacterial Agents, Pharmacodynamics, Cattle, Female, medicine.drug |
| الوصف: | The antimicrobial properties of amoxicillin were determined for the bovine respiratory tract pathogens, Mannheima haemolytica and Pasteurella multocida. Minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC) and time-kill curves were established. Pharmacokinetic (PK)/pharmacodynamic (PD) modelling of the time-kill data, based on the sigmoidal Emax equation, generated parameters for three levels of efficacy, namely bacteriostatic, bactericidal (3log10 reduction) and 4log10 reduction in bacterial counts. For these levels, mean AUC(0-24 h) /MIC serum values for M. haemolytica were 29.1, 57.3 and 71.5 h, respectively, and corresponding values for P. multocida were 28.1, 44.9 and 59.5 h. Amoxicillin PK was determined in calf serum, inflamed (exudate) and noninflamed (transudate) tissue cage fluids, after intramuscular administration of a depot formulation at a dosage of 15 mg/kg. Mean residence times were 16.5 (serum), 29.6 (exudate) and 29.0 h (transudate). Based on serum MICs, integration of in vivo PK and in vitro PD data established maximum concentration (Cmax )/MIC ratios of 13.9:1 and 25.2:1, area under concentration-time curve (AUC0-∞ )/MIC ratios of 179 and 325 h and T>MIC of 40.3 and 57.6 h for P. multocida and M. haemolytica, respectively. Monte Carlo simulations for a 90% target attainment rate predicted single dose to achieve bacteriostatic and bactericidal actions over 48 h of 17.7 and 28.3 mg/kg (M. haemolytica) and 17.7 and 34.9 mg/kg (P. multocida). |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 0140-7783 1365-2885 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57f56caafbdb7f8ac094f3cf149dcd39Test https://hal.archives-ouvertes.fr/hal-01606653Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....57f56caafbdb7f8ac094f3cf149dcd39 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 01407783 13652885 |
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