Genetic Analysis of Families with Autoimmune Diabetes and Thyroiditis: Evidence for Common and Unique Genes
| العنوان: | Genetic Analysis of Families with Autoimmune Diabetes and Thyroiditis: Evidence for Common and Unique Genes |
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| المؤلفون: | Brian K. Golden, David A. Greenberg, Yoshiyuki Ban, Yaron Tomer, Erlinda Concepcion, Lara Levin |
| المصدر: | The Journal of Clinical Endocrinology & Metabolism. 90:4904-4911 |
| بيانات النشر: | The Endocrine Society, 2005. |
| سنة النشر: | 2005 |
| مصطلحات موضوعية: | Adult, Male, endocrine system, Candidate gene, medicine.medical_specialty, Linkage disequilibrium, endocrine system diseases, Endocrinology, Diabetes and Metabolism, Clinical Biochemistry, Human leukocyte antigen, Thyroglobulin, Biochemistry, Article, Linkage Disequilibrium, HLA-DR3 Antigen, Endocrinology, Antigens, CD, immune system diseases, HLA-DQ Antigens, Internal medicine, Genetic predisposition, medicine, HLA-DQ beta-Chains, Humans, Insulin, CTLA-4 Antigen, Genetic Predisposition to Disease, Child, Family Health, HLA-DQ Antigen, business.industry, Histocompatibility Testing, Biochemistry (medical), Haplotype, Thyroiditis, Autoimmune, nutritional and metabolic diseases, Transmission disequilibrium test, Antigens, Differentiation, Variable number tandem repeat, Diabetes Mellitus, Type 1, Haplotypes, Tandem Repeat Sequences, Immunology, Female, Lod Score, business |
| الوصف: | Epidemiological data suggest a common genetic susceptibility to type 1 diabetes (T1D) and autoimmune thyroid disease (AITD).Our objective was to identify the joint susceptibility genes for T1D and AITD.We conducted a family-based linkage and association study.The study took place at an academic medical center.Participants included 55 multiplex families (290 individuals) in which T1D and AITD clustered (T1D-AITD families).We conducted tests for linkage and family-based associations (transmission disequilibrium test) with four candidate genes: human leukocyte antigen (HLA), cytotoxic T lymphocyte-associated antigen 4 (CTLA-4), insulin variable number of tandem repeats (VNTR), and thyroglobulin.Linkage evidence to HLA appeared when subjects with either T1D or AITD were considered affected [maximum LOD score (MLS), 2.2]. The major HLA haplotype contributing to the shared susceptibility was DR3-DQB1*0201, with DR3 conferring most of the shared risk. The CTLA-4 gene showed evidence for linkage only when individuals with both T1D and AITD were considered affected (MLS, 1.7), and the insulin VNTR showed evidence for linkage when individuals with either T1D or AITD were considered affected (MLS, 1.9); i.e. it may contribute to the familial aggregation of T1D and AITD.The HLA class II locus contributes to the shared risk for T1D and AITD, and the major HLA haplotype contributing to this association is DR3-DQB1*0201. Additional non-HLA loci contribute to the joint susceptibility to T1D and AITD, and two potential candidates include the CTLA-4 and insulin VNTR loci. |
| تدمد: | 1945-7197 0021-972X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::576b45bdc5f587dbca82faa25819a6c9Test https://doi.org/10.1210/jc.2004-2236Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....576b45bdc5f587dbca82faa25819a6c9 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19457197 0021972X |
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