Activation, Deficiency, and Reduced IFN-γ Production of Mucosal-Associated Invariant T Cells in Patients with Inflammatory Bowel Disease
| العنوان: | Activation, Deficiency, and Reduced IFN-γ Production of Mucosal-Associated Invariant T Cells in Patients with Inflammatory Bowel Disease |
|---|---|
| المؤلفون: | Hyun Soo Kim, Yong-Wook Park, Han Deok Kwak, Jae Kyun Ju, Seon-Young Park, Seung-Jung Kee, Ki-Jeong Park, Hye-Mi Jin, Young-Nan Cho |
| المصدر: | J Innate Immun Journal of Innate Immunity, Pp 1-12 (2020) |
| بيانات النشر: | S. Karger AG, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, Adult, Male, lcsh:Internal medicine, lcsh:Medicine, Mucosal associated invariant T cell, migration, Lymphocyte Activation, Inflammatory bowel disease, Mucosal-Associated Invariant T Cells, 03 medical and health sciences, Interferon-gamma, Young Adult, 0302 clinical medicine, inflammatory bowel disease, Cell Movement, interferon-γ, MHC class I, medicine, Immunology and Allergy, CXCL10, Humans, lcsh:RC31-1245, CXCL16, biology, NFATC Transcription Factors, business.industry, T-cell receptor, lcsh:R, Middle Aged, medicine.disease, Inflammatory Bowel Diseases, digestive system diseases, Immunity, Innate, CCL20, 030104 developmental biology, 030228 respiratory system, Immunology, biology.protein, activation, Female, CCL25, Chemokines, business, Research Article |
| الوصف: | Mucosal-associated invariant T (MAIT) cells are innate-like T cells that can activate either in response to T-cell receptor (TCR) engagement or through activating cytokines and play an important role in autoimmune disorders. The study examined the level and function of MAIT cells in patients with inflammatory bowel disease (IBD). Circulating MAIT cell levels were significantly reduced in IBD patients. This MAIT cell deficiency was correlated with IBD disease activity grades, hemoglobin, and CRP. IFN-γ production of circulating MAIT cells in response to both MHC class 1b-like related protein (MR1)-dependent and -independent stimulations was decreased in IBD patients, which was partially associated with reduced activation of nuclear factor of activated T cells 1 (NFAT1) transcription factor, a main regulator of IFN-γ production. Expression levels of CD69, programmed death-1 (PD-1), and annexin V in MAIT cells were elevated in IBD patients. CCL20, CXCL10, CXCL16, and CCL25 were expressed higher in inflamed intestinal tissues than in noninflamed tissues. This study demonstrates that circulating MAIT cells are activated and numerically and functionally deficient in IBD patients. Furthermore, activated MAIT cells have the potential to migrate to inflamed tissues. These findings suggest an important role of MAIT cells in mucosal immunity in IBD. |
| اللغة: | English |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57281fc424a5dd904079ca906ccca68eTest https://europepmc.org/articles/PMC7506267Test/ |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....57281fc424a5dd904079ca906ccca68e |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |