Hallucinations, somatic‐functional disorders of PD‐DLB as expressions of thalamic dysfunction
| العنوان: | Hallucinations, somatic‐functional disorders of PD‐DLB as expressions of thalamic dysfunction |
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| المؤلفون: | Laura Bonanni, Marco Onofrj, Alberto J. Espay, Stefano L. Sensi, Stefano Delli Pizzi |
| المصدر: | Mov Disord |
| بيانات النشر: | Wiley, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Lewy Body Disease, 0301 basic medicine, Psychosis, Parkinson's disease, Hallucinations, Thalamocortical dysrhythmia, Context (language use), behavioral disciplines and activities, Article, Delusions, 03 medical and health sciences, 0302 clinical medicine, Thalamus, Neural Pathways, mental disorders, medicine, Humans, Dementia, Attention, Theta Rhythm, Cognitive decline, Somatoform Disorders, Default mode network, Cerebral Cortex, Dementia with Lewy bodies, business.industry, Electroencephalography, Parkinson Disease, medicine.disease, 030104 developmental biology, Psychotic Disorders, Neurology, Neurology (clinical), business, Neuroscience, 030217 neurology & neurosurgery |
| الوصف: | Hallucinations, delusions, and functional neurological manifestations (conversion and somatic symptom disorders) of Parkinson's disease (PD) and dementia with Lewy bodies increase in frequency with disease progression, predict the onset of cognitive decline, and eventually blend with and are concealed by dementia. These symptoms share the absence of reality constraints and can be considered comparable elements of the PD-dementia with Lewy bodies psychosis. We propose that PD-dementia with Lewy bodies psychotic disorders depend on thalamic dysfunction promoting a theta burst mode and subsequent thalamocortical dysrhythmia with focal cortical coherence to theta electroencephalogram rhythms. This theta electroencephalogram activity, also called fast-theta or pre-alpha, has been shown to predict cognitive decline and fluctuations in Parkinson's disease with dementia and dementia with Lewy bodies. These electroencephalogram alterations are now considered a predictive marker for progression to dementia. The resulting thalamocortical dysrhythmia inhibits the frontal attentional network and favors the decoupling of the default mode network. As the default mode network is involved in integration of self-referential information into conscious perception, unconstrained default mode network activity, as revealed by recent imaging studies, leads to random formation of connections that link strong autobiographical correlates to trivial stimuli, thereby producing hallucinations, delusions, and functional neurological disorders. The thalamocortical dysrhythmia default mode network decoupling hypothesis provides the rationale for the design and testing of novel therapeutic pharmacological and nonpharmacological interventions in the context of PD, PD with dementia, and dementia with Lewy bodies. © 2019 International Parkinson and Movement Disorder Society. |
| تدمد: | 1531-8257 0885-3185 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5723a25a403438f83d70f5d5c9381165Test https://doi.org/10.1002/mds.27781Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....5723a25a403438f83d70f5d5c9381165 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15318257 08853185 |
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