Risk Factors of Persistent Hydrocephalus in Children with Brain Tumor: A Retrospective Analysis
| العنوان: | Risk Factors of Persistent Hydrocephalus in Children with Brain Tumor: A Retrospective Analysis |
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| المؤلفون: | Chiara Pilotto, Serena D’Agostini, Paola Cogo, F. Tuniz, Eva Passone, Miran Skrap, Ilaria Liguoro, Serena Scaravetti |
| المصدر: | Pediatric Neurosurgery. 56:205-212 |
| بيانات النشر: | S. Karger AG, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Male, Pediatrics, medicine.medical_specialty, Tumor resection, Brain tumor, Logistic regression, Children, Hydrocephalus, Risk factor, Cerebrospinal fluid, Risk Factors, Retrospective analysis, medicine, Humans, Prospective Studies, Child, Retrospective Studies, Brain Neoplasms, business.industry, Infant, Retrospective cohort study, General Medicine, medicine.disease, Pediatrics, Perinatology and Child Health, Female, Surgery, Neurology (clinical), business |
| الوصف: | Object: Hydrocephalus is one of the main complications of brain tumors in children, being present in about 50% of cases at the time of the tumor diagnosis and persisting up to 10–40% of cases after surgical resection. This is a single-institution retrospective study on the variables that may predict the need for treatment of persistent hydrocephalus in pediatric patients presenting with a brain tumor. Methods: Retrospective case note review of 43 newly diagnosed brain tumors in children referred between April 2012 and January 2018 to our regional pediatric neuro-oncology service was carried out. Diagnosis of hydrocephalus was carried out using both preoperative and postoperative MRI to determine Evans’ index (EI) and the fronto-occipital horn ratio (FOHR) from each scan. Simple logistic regression was used to analyze categorical variables as appropriate. A p value Results: Forty-three children were analyzed, 26 males and 17 females with a median age at diagnosis 10.4 years (IQR: 5.2–13.5). Hydrocephalus was present in 22/43 children (51%) preoperatively; in 8/22 children (36%) with hydrocephalus undergoing tumor resection, hydrocephalus persisted also in the postoperative period. An EI >0.34 (p = 0.028) and an FOHR >0.46 (p = 0.05) before surgery were associated with a higher prevalence of persistent hydrocephalus and therefore to the need for a cerebrospinal fluid drain device in the postoperative phase. Conclusion: Preoperative identification of children at risk for developing persistent hydrocephalus would avoid delays in planning the permanent cerebrospinal fluid drain devices. This study finds that an EI >0.34 and an FOHR >0.46 at diagnosis could impact on the therapeutic management of children with hydrocephalus associated with brain tumors. Prospective and larger-scale studies are needed to standardize this approach. |
| تدمد: | 1423-0305 1016-2291 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56a257aadc53754f4b16d42533d5f2e8Test https://doi.org/10.1159/000513732Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....56a257aadc53754f4b16d42533d5f2e8 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14230305 10162291 |
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