Twist Expression Predicts Poor Clinical Outcome of Patients with Clear Cell Carcinoma of the Ovary
| العنوان: | Twist Expression Predicts Poor Clinical Outcome of Patients with Clear Cell Carcinoma of the Ovary |
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| المؤلفون: | Hiroaki Kajiyama, Fumitaka Kikkawa, Eiko Yamamoto, Akihiro Nawa, Satoyo Hosono, Seiji Nomura, Kiyosumi Shibata, Mikio Terauchi, Kazuhiko Ino |
| المصدر: | Oncology. 71:394-401 |
| بيانات النشر: | S. Karger AG, 2006. |
| سنة النشر: | 2006 |
| مصطلحات موضوعية: | Adult, Cancer Research, Pathology, medicine.medical_specialty, Biology, Disease-Free Survival, Twist transcription factor, Predictive Value of Tests, Cell Line, Tumor, Biomarkers, Tumor, medicine, Humans, Clinical significance, Twist, Survival rate, Aged, Ovarian Neoplasms, Twist-Related Protein 1, Anatomical pathology, General Medicine, Middle Aged, Prognosis, medicine.disease, Survival Rate, Oncology, Multivariate Analysis, Clear cell carcinoma, Disease Progression, Cancer research, Adenocarcinoma, Immunohistochemistry, Female, Adenocarcinoma, Clear Cell |
| الوصف: | Objectives: Twist is a highly conserved basic helix-loop-helix transcription factor that regulates the expression of E-cadherin and promotes the epithelial-mesenchymal transition, which is critical for tumor infiltration. We examined the distribution and expression of this molecule in clear cell carcinoma of the ovary (CCC) to elucidate their clinical significance. Methods: Paraffin sections from CCC tissues (n = 27) were immunostained with Twist antibody and staining intensities were evaluated. Stratified with various clinicopathological factors, overall survival (OS) and progression-free survival (PFS) were evaluated. Results: In the 27 carcinomas, negative Twist immunoexpression was observed in 14 cases (51.9%), and positive immunoexpression in 13 (48.1%). Twist, when categorized into negative versus positive expression, was associated with FIGO stage and peritoneal cytology. In addition, positive Twist expression significantly predicted a poorer OS and PFS compared with negative expression (p < 0.0001). Furthermore, the multivariate analyses revealed that positive Twist expression was an independent prognostic factor for OS and PFS of patients with CCC in this study (p = 0.0077 and 0.0033, respectively). Conclusion: The current findings suggest that the assessment of Twist immunoreactivity may be a useful prognostic indicator and that Twist may play a critical role in the progression of CCC. |
| تدمد: | 1423-0232 0030-2414 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::555d3f98039f043a1686db3ad533afd6Test https://doi.org/10.1159/000107108Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....555d3f98039f043a1686db3ad533afd6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14230232 00302414 |
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