Utility and limitations of Hepascore and transient elastography to detect advanced hepatic fibrosis in HFE hemochromatosis

التفاصيل البيبلوغرافية
العنوان: Utility and limitations of Hepascore and transient elastography to detect advanced hepatic fibrosis in HFE hemochromatosis
المؤلفون: Grant A. Ramm, Tiffany Sandra Wai Ling Khoo, Martin B. Delatycki, Puraskar Pateria, Lyle C. Gurrin, Thomas Worland, Louise E. Ramm, Richard Skoien, Amanda Nicoll, Gregory J. Anderson, Adam G Testro, Sim Yee Ong, Lawrie W. Powell, John K. Olynyk
المصدر: Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
سنة النشر: 2021
مصطلحات موضوعية: Adult, Liver Cirrhosis, Male, medicine.medical_specialty, Cirrhosis, Science, Biopsy, Liver fibrosis, Gastroenterology, Sensitivity and Specificity, Article, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Predictive Value of Tests, Internal medicine, medicine, Humans, 030212 general & internal medicine, Aspartate Aminotransferases, Hemochromatosis Protein, Hemochromatosis, Liver diseases, Multidisciplinary, Receiver operating characteristic, medicine.diagnostic_test, business.industry, Platelet Count, Reproducibility of Results, Middle Aged, medicine.disease, Liver, Liver biopsy, Hereditary hemochromatosis, Disease Progression, Medicine, Elasticity Imaging Techniques, 030211 gastroenterology & hepatology, Female, Elastography, Transient elastography, Hepatic fibrosis, business, Biomarkers
الوصف: Aspartate aminotransferase-to-platelet ratio index (APRI) and Fibrosis-4 Index (Fib4) have been validated against liver biopsy for detecting advanced hepatic fibrosis in HFE hemochromatosis. We determined the diagnostic utility for advanced hepatic fibrosis of Hepascore and transient elastography compared with APRI and Fib4 in 134 newly diagnosed HFE hemochromatosis subjects with serum ferritin levels > 300 µg/L using area under the receiver operator characteristic curve (AUROC) analysis and APRI- (> 0.44) or Fib4- (> 1.1) cut-offs for AHF, or a combination of both. Compared with APRI, Hepascore demonstrated an AUROC for advanced fibrosis of 0.69 (95% CI 0.56–0.83; sensitivity = 69%, specificity = 65%; P = 0.01) at a cut-off of 0.22. Using a combination of APRI and Fib4, the AUROC for Hepascore for advanced fibrosis was 0.70 (95% CI 0.54–0.86, P = 0.02). Hepascore was not diagnostic for detection of advanced fibrosis using the Fib4 cut-off. Elastography was not diagnostic using either APRI or Fib4 cut-offs. Hepascore and elastography detected significantly fewer true positive or true negative cases of advanced fibrosis compared with APRI and Fib4, except in subjects with serum ferritin levels > 1000 µg/L. In comparison with APRI or Fib4, Hepascore or elastography may underdiagnose advanced fibrosis in HFE Hemochromatosis, except in individuals with serum ferritin levels > 1000 µg/L.
تدمد: 2045-2322
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5533d71db3facdfb30c9bb70d4f827f8Test
https://pubmed.ncbi.nlm.nih.gov/34282177Test
حقوق: OPEN
رقم الانضمام: edsair.doi.dedup.....5533d71db3facdfb30c9bb70d4f827f8
قاعدة البيانات: OpenAIRE