Be careful about MICs to amoxicillin for patients with Streptococci-related infective endocarditis
| العنوان: | Be careful about MICs to amoxicillin for patients with Streptococci-related infective endocarditis |
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| المؤلفون: | S. Corvec, Christophe Isnard, Hervé Jacquier, Audrey Mérens, Olivier Barraud, Marlène Amara, A. Le Monnier, Julie Lourtet-Hascoët, E. Thomas, C. Piau, Vincent Cattoir, Benoit Pilmis, Geneviève Héry-Arnaud, J.-R. Zahar, G. Péan de Ponfilly, David Boutoille, S. Reissier, E. Bonnet, Eric Farfour |
| المساهمون: | Centre hospitalier Saint-Joseph [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service de Bactériologie, Virologie, Hygiène [CHU Limoges], CHU Limoges, CHU Pontchaillou [Rennes], Service de Microbiologie [CHU Caen], Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN), Groupe de Recherche sur l'Adaptation Microbienne (GRAM 2.0), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Université de Caen Normandie (UNICAEN), Normandie Université (NU), Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Centre Hospitalier de Versailles André Mignot (CHV), Hôpital d'Instruction des Armées Begin, Service de Santé des Armées, Hôpital Foch [Suresnes], Service de bactériologie et hygiène hospitalière [Nantes], Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes), Hôpital Lariboisière-Fernand-Widal [APHP], Hôpital Avicenne [AP-HP], Clinique Pasteur [Toulouse], Interactions hôte et microorganismes des épithéliums, Normandie Université (NU)-Normandie Université (NU), Service des maladies infectieuses et tropicales [CHU Nantes], Centre hospitalier universitaire de Nantes (CHU Nantes) |
| المصدر: | International Journal of Antimicrobial Agents International Journal of Antimicrobial Agents, Elsevier, 2019, 53 (6), pp.850-854. ⟨10.1016/j.ijantimicag.2019.03.002⟩ |
| بيانات النشر: | HAL CCSD, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0301 basic medicine, Male, Antibiotics, 0302 clinical medicine, Interquartile range, Risk Factors, Pharmacology (medical), 030212 general & internal medicine, ComputingMilieux_MISCELLANEOUS, Aged, 80 and over, Endocarditis, General Medicine, Middle Aged, Hospitals, 3. Good health, Cardiac surgery, Anti-Bacterial Agents, Infectious Diseases, [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology, Infective endocarditis, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Female, France, medicine.drug, Microbiology (medical), Adult, medicine.medical_specialty, Adolescent, medicine.drug_class, 030106 microbiology, Microbial Sensitivity Tests, 03 medical and health sciences, Minimum inhibitory concentration, Young Adult, Internal medicine, Streptococcal Infections, medicine, Humans, Aged, Retrospective Studies, Native Valve Endocarditis, business.industry, Amoxicillin, Streptococcus, medicine.disease, Survival Analysis, [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, business |
| الوصف: | Background A variety of microorganisms can cause infective endocarditis (IE), with Staphylococci and Streptococci accounting for the majority of cases. Streptococci are a common cause of community-acquired IE but few studies have focused on this subgroup of endocarditis. Methods A retrospective multicentre study was conducted between 2012 and 2017 in 12 hospital centres in France. Data were extracted from the local diagnosis-related group database and matched with microbiological results. After identification, the records were retrospectively analysed. Results A total of 414 patients with streptococcal endocarditis were included. The patients were predominantly male (72.8%) and the median age was 73.2 years (interquartile range [IQR] 61.3-80.9). The majority of patients (70.6%) had native valve endocarditis. Embolic complications were seen in 38.8% of patients. Viridans group Streptococci (VGS) and bovis-equinus group Streptococci (BGS) accounted for 52.4% and 34.5% of isolated strains, respectively. Minimum inhibitory concentrations (MICs) of amoxicillin were 2 mg/L for 59.6%, 27% and 1% of isolates, respectively. In-hospital mortality for patients with Streptococci-related IE was 17.8%. In multivariate analysis, the only factor associated with in-hospital mortality was MIC for amoxicillin between 0.25 and 2 mg/L (P = 0.04; OR = 2.23 [95% confidence interval (CI) 1.03-4.88]) whereas performance of cardiac surgery for IE was a protective factor (P = 0.001, OR = 0.23 [95% CI 0.1-0.56]). Conclusions IE remains a serious and deadly disease despite recent advances in diagnosis and treatment. Adaptation of antibiotic doses to MICs for amoxicillin and surgery may improve patient outcome. |
| اللغة: | English |
| تدمد: | 0924-8579 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5460b2f11801358797a4dc716f6cbe75Test https://hal-normandie-univ.archives-ouvertes.fr/hal-02153942Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....5460b2f11801358797a4dc716f6cbe75 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 09248579 |
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