Effect of 4 years subcutaneous insulin infusion treatment on albuminuria, kidney function and HbA1ccompared with multiple daily injections: a longitudinal follow-up study
التفاصيل البيبلوغرافية
العنوان:
Effect of 4 years subcutaneous insulin infusion treatment on albuminuria, kidney function and HbA1ccompared with multiple daily injections: a longitudinal follow-up study
Aim The effect of insulin pump [continuous subcutaneous insulin infusion (CSII)] treatment on diabetes complications in a modern clinical setting is largely unknown. We investigated the effect of 4 years CSII treatment on HbA1c, albuminuria and kidney function compared with multiple daily injections (MDI) in a single-centre clinical setting. Methods All patients initiating CSII treatment from 2004 to 2010 and followed for at least 4 years were included in the study: 193 people with Type 1 diabetes were matched (1 : 2) with 386 patients treated with MDI in the same period. Matching was based on diabetes duration, gender, HbA1c and normo-, micro- or macroalbuminuria at baseline. Urinary albumin/creatinine ratio (UACR) was measured yearly and annual change assessed from linear regression. Results CSII- vs. MDI-treated patients were comparable at baseline. After 4 years, HbA1c was 62 ± 11 vs. 68 ± 11 mmol/mol (7.8 ± 1.0 vs. 8.4 ± 1.0%) (P
