Axon Regeneration Requires a Conserved MAP Kinase Pathway
| العنوان: | Axon Regeneration Requires a Conserved MAP Kinase Pathway |
|---|---|
| المؤلفون: | Erik M. Jorgensen, Michael Bastiani, Paola Nix, Linda Hauth, Marc Hammarlund |
| المصدر: | Science. 323:802-806 |
| بيانات النشر: | American Association for the Advancement of Science (AAAS), 2009. |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | Aging, MAP Kinase Kinase 4, MAP Kinase Signaling System, medicine.medical_treatment, Growth Cones, Models, Biological, Article, medicine, Animals, Axon, Caenorhabditis elegans, Caenorhabditis elegans Proteins, Growth cone, gamma-Aminobutyric Acid, Motor Neurons, Multidisciplinary, MAP kinase kinase kinase, biology, Regeneration (biology), Axotomy, Motor neuron, MAP Kinase Kinase Kinases, Axons, Nerve Regeneration, Cell biology, medicine.anatomical_structure, nervous system, Mitogen-activated protein kinase, Mutation, biology.protein, RNA Interference, Neuron, Mitogen-Activated Protein Kinases |
| الوصف: | Regeneration of injured neurons can restore function, but most neurons regenerate poorly or not at all. The failure to regenerate in some cases is due to a lack of activation of cell-intrinsic regeneration pathways. These pathways might be targeted for the development of therapies that can restore neuron function after injury or disease. Here, we show that the DLK-1 mitogen-activated protein (MAP) kinase pathway is essential for regeneration in Caenorhabditis elegans motor neurons. Loss of this pathway eliminates regeneration, whereas activating it improves regeneration. Further, these proteins also regulate the later step of growth cone migration. We conclude that after axon injury, activation of this MAP kinase cascade is required to switch the mature neuron from an aplastic state to a state capable of growth. |
| تدمد: | 1095-9203 0036-8075 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::543500ce5902e37d9b98de05d5c84fddTest https://doi.org/10.1126/science.1165527Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....543500ce5902e37d9b98de05d5c84fdd |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10959203 00368075 |
|---|