Nutritional markers and proteome in patients undergoing treatment for pulmonary tuberculosis differ by geographic region
| العنوان: | Nutritional markers and proteome in patients undergoing treatment for pulmonary tuberculosis differ by geographic region |
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| المؤلفون: | Komal Kedia, Marc H Weiner, Joseph Keane, Jason P. Wendler, Payam Nahid, Aaron T. Wright, David M. Lewinsohn, Leah G. Jarsberg, Jon M. Jacobs, George Sigal, Marina A. Gritsenko, Richard D. Smith, Tujin Shi, Paul D. Piehowski |
| المساهمون: | Subbian, Selvakumar |
| المصدر: | PLoS ONE, Vol 16, Iss 5, p e0250586 (2021) PloS one, vol 16, iss 5 PLoS ONE |
| بيانات النشر: | Public Library of Science (PLoS), 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Bacterial Diseases, 0301 basic medicine, Proteomics, Male, Proteome, Proteomes, Organic chemistry, Biochemistry, South Africa, Medical Conditions, 0302 clinical medicine, Medicine and Health Sciences, Ethnicities, 2.1 Biological and endogenous factors, Uganda, Nutritional Physiological Phenomena, 030212 general & internal medicine, Aetiology, Vitamin A, Immune Response, Lung, Fluids, screening and diagnosis, Multidisciplinary, Physics, Acute-phase protein, Vitamins, Pulmonary, Middle Aged, Physical sciences, Chemistry, Detection, Treatment Outcome, Infectious Diseases, 6.1 Pharmaceuticals, Geographic regions, Medicine, Female, Infection, Research Article, 4.2 Evaluation of markers and technologies, Adult, States of Matter, medicine.medical_specialty, Treatment response, Tuberculosis, General Science & Technology, Science, Immunology, Clinical Trials and Supportive Activities, Chemical compounds, 03 medical and health sciences, Young Adult, Signs and Symptoms, Rare Diseases, Pulmonary tuberculosis, Clinical Research, Internal medicine, Organic compounds, medicine, Humans, In patient, Tuberculosis, Pulmonary, Nutrition, African People, Inflammation, business.industry, Prevention, Biology and Life Sciences, Proteins, Evaluation of treatments and therapeutic interventions, Acute Phase Proteins, Liquids, Mycobacterium tuberculosis, Tropical Diseases, medicine.disease, Lipid Metabolism, Clinical trial, 030104 developmental biology, Good Health and Well Being, Spain, People and Places, North America, Population Groupings, Clinical Medicine, business, Biomarkers |
| الوصف: | Introduction Contemporary phase 2 TB disease treatment clinical trials have found that microbiologic treatment responses differ between African versus non-African regions, the reasons for which remain unclear. Understanding host and disease phenotypes that may vary by region is important for optimizing curative treatments. Methods We characterized clinical features and the serum proteome of phase 2 TB clinical trial participants undergoing treatment for smear positive, culture-confirmed TB, comparing host serum protein expression in clinical trial participants enrolled in African and Non-African regions. Serum samples were collected from 289 participants enrolled in the Centers for Disease Control and Prevention TBTC Study 29 (NCT00694629) at time of enrollment and at the end of the intensive phase (after 40 doses of TB treatment). Results After a peptide level proteome analysis utilizing a unique liquid chromatography IM-MS platform (LC-IM-MS) and subsequent statistical analysis, a total of 183 core proteins demonstrated significant differences at both baseline and at week 8 timepoints between participants enrolled from African and non-African regions. The majority of the differentially expressed proteins were upregulated in participants from the African region, and included acute phase proteins, mediators of inflammation, as well as coagulation and complement pathways. Downregulated proteins in the African population were primarily linked to nutritional status and lipid metabolism pathways. Conclusions We have identified differentially expressed nutrition and lipid pathway proteins by geographic region in TB patients undergoing treatment for pulmonary tuberculosis, which appear to be associated with differential treatment responses. Future TB clinical trials should collect expanded measures of nutritional status and further evaluate the relationship between nutrition and microbiologic treatment response. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1932-6203 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54054771901f8308e9de0a3ceb59c4b7Test https://doaj.org/article/b9145d89909b47d4854d0bccdbebc6efTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....54054771901f8308e9de0a3ceb59c4b7 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19326203 |
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