Role of Estrogen and Its Receptors in Adipose Tissue Glucose Metabolism in Pre- and Postmenopausal Women
| العنوان: | Role of Estrogen and Its Receptors in Adipose Tissue Glucose Metabolism in Pre- and Postmenopausal Women |
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| المؤلفون: | Fozia Ahmed, Prasad G Kamble, Susanne Hetty, Giovanni Fanni, Milica Vranic, Assel Sarsenbayeva, Robin Kristófi, Kristina Almby, Maria K Svensson, Maria J Pereira, Jan W Eriksson |
| المصدر: | The Journal of Clinical Endocrinology & Metabolism. 107:e1879-e1889 |
| بيانات النشر: | The Endocrine Society, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Endocrinology, Diabetes and Metabolism, Biochemistry (medical), Clinical Biochemistry, Estrogen Receptor alpha, menopause, Reproduktionsmedicin och gynekologi, Estrogens, Endocrinology and Diabetes, Polymorphism, Single Nucleotide, Biochemistry, adipose tissue, Postmenopause, Cholesterol, Glucose, Endocrinology, Adipose Tissue, Diabetes Mellitus, Type 2, Receptors, Estrogen, estradiol, insulin resistance, Obstetrics, Gynecology and Reproductive Medicine, Endokrinologi och diabetes, Humans, Female, type 2 diabetes |
| الوصف: | Context Reduced estrogen levels in postmenopausal women predispose them to metabolic side effects, including insulin resistance and type 2 diabetes; however, the cellular mechanisms are not well understood. Objective This work aimed to study the expression of estrogen receptors in adipose tissue from pre- and postmenopausal women and the effects of estradiol (E2) on glucose uptake of adipocytes. Methods Subcutaneous (SAT) and visceral adipose tissue (VAT) obtained from pre- and postmenopausal women (19-51 and 46-75 years old, respectively) were used to measure gene expression of ESR1 and ESR2. SAT tissue was incubated with E2, and glucose uptake and estrogen receptor levels were measured. Polymorphisms in ESR1 and ESR2 were addressed in public databases to identify single nucleotide polymorphisms associated with metabolic traits. Results ESR2 expression was lower in pre- vs postmenopausal women, corresponding to lower ESR1:ESR2 gene expression ratio in postmenopausal women. In premenopausal women, the expression of ESR1 was higher in VAT than in SAT. In both pre- and postmenopausal women, ESR2 expression was lower in VAT than in SAT. In late, but not pre- or early postmenopausal women, E2 reduced glucose uptake and GLUT4 protein and increased expression of ESR2. ESR1 polymorphisms were associated with weight, body fat distribution, and total cholesterol, and ESR2 polymorphisms were associated with total cholesterol and triglyceride levels and with body fat percentage. Conclusion E2 inhibits glucose utilization in human adipocytes in late postmenopausal women. Changes in glucose utilization over time since menopause may be explained by a lower ESR1:ESR2 ratio. This can have clinical implications on the timing of estrogen treatment in postmenopausal women. |
| وصف الملف: | application/pdf |
| تدمد: | 1945-7197 0021-972X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53fd447fd508411eb0fc65121b353bd5Test https://doi.org/10.1210/clinem/dgac042Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....53fd447fd508411eb0fc65121b353bd5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19457197 0021972X |
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