Introduction Lipohypertrophy (LH) is one of the most common complications of insulin therapy. We conducted a prospective study in 18 UK centres to assess the impact of a targeted LH intervention on a range of clinical, biological and socio-economic parameters. Methods Seventy-five insulin-injecting patients were recruited randomly and were followed prospectively for 3–6 months, with results compared to baseline values. Interventions included the use of an intensive education program and a switch to a 4 mm pen needle. Results At all injection sites LH decreased significantly by the end of the study, either disappearing completely or shrinking by approximately 50% from its original diameter. Injections into LH decreased by more than 75% by the end. Most patients were not correctly rotating injection sites at the beginning but by the end most were, by a 5-fold margin. Only 1/3 of our subjects used the 4 mm needle at the beginning of the study, however, virtually all did by study end. The mean HbA1c improved by more than 4 mmol/L and there were significantly lower levels of unexpected hypoglycaemia and glucose variability. Total daily doses of insulin dropped by an average of 5.6 IU by study end. Conclusions We believe the impressive clinical improvements seen with training to prevent LH can be achieved by wide adoption of the interventions outlined in this study.
