Renal function dependent association of AGTR1 polymorphism (A1166C) and Electrocardiographic left-ventricular hypertrophy
| العنوان: | Renal function dependent association of AGTR1 polymorphism (A1166C) and Electrocardiographic left-ventricular hypertrophy |
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| المؤلفون: | Hans L. Hillege, Wiek H. van Gilst, Paul E. de Jong, Jan A. Kors, Gerrit van der Steege, Tom D. J. Smilde, Mike W. Zuurman, Dirk J. van Veldhuisen, Gerjan Navis, Adriaan A. Voors |
| المساهمون: | Medical Informatics, Life Course Epidemiology (LCE), Cardiovascular Centre (CVC), Lifestyle Medicine (LM), Groningen Kidney Center (GKC), Vascular Ageing Programme (VAP) |
| المصدر: | American Journal of Hypertension, 20(10), 1097-1103. Oxford University Press American Journal of Hypertension, 20(10), 1097-1103. Oxford Univ. Press, New York |
| سنة النشر: | 2007 |
| مصطلحات موضوعية: | Male, DELETION POLYMORPHISM, BLOOD-PRESSURE, Kidney, Left ventricular hypertrophy, Muscle hypertrophy, polymorphism, Renin-Angiotensin System, Electrocardiography, Risk Factors, Polymorphism (computer science), HUMAN ARTERIES, Medicine, Prospective Studies, education.field_of_study, renin angiotensin system, CONVERTING-ENZYME GENE, Homozygote, Middle Aged, ANGIOTENSIN-II, Regression Analysis, Female, Hypertrophy, Left Ventricular, Adult, INSERTION/DELETION POLYMORPHISM, medicine.medical_specialty, Population, Renal function, ALDOSTERONE SYSTEM, Peptidyl-Dipeptidase A, Polymorphism, Single Nucleotide, Receptor, Angiotensin, Type 1, Internal medicine, Diabetes mellitus, Internal Medicine, Humans, PREVEND, cardiovascular diseases, education, Aged, business.industry, renal function, left-ventricular hypertrophy, DIABETES-MELLITUS, KIDNEY-DISEASE, medicine.disease, Angiotensin II, Cross-Sectional Studies, Logistic Models, Endocrinology, business, Kidney disease, ACE I/D POLYMORPHISM |
| الوصف: | Background: The association of renin-angiotensin system (RAS) polymorphisms and left-ventricular hypertrophy (LVH) may depend on the presence of risk factors for LVH, such as renal dysfunction. We studied whether renal function modulates the association between RAS polymorphisms and LVH in a cross-sectional study of 8592 inhabitants of Groningen.Methods: Left-ventricular hypertrophy was determined with electrocardiograms, using the Cornell voltage-duration product. The following RAS polymorphisms were determined: angiotensin II type-1 receptor (AGTR1 A1166C), angiotensin-converting enzyme (ACE) insertion/deletion (I/ D), and angiotensinogen (AGT G-6A). The AGTR1 A1166C and ACE I/D polymorphisms were in Hardy-Weinberg equilibrium.Results: Electrocardiographic LVH was present in 417 (5.0%) subjects. Subjects with LVH were older (53 v 49 years) and overall had more cardiovascular risk factors. Using logistic regression, creatinine clearance interacted with the relationship between the AGTR1 A1166C poly- morphism and LVH (0, -0.19; P = .033). In subjects with the CC genotype, in contrast to carriers of an A allele, the prevalence of LVH increased with more pronounced renal dysfunction. Creatinine clearance also interacted with the relationship between the ACE I/D polymorphism and LVH (0, 0.12; P = .037), although less strongly, and the other way around. Creatinine clearance did not influence the association between the AGT G-6A polymorphism and LVH (beta, -0.006; P = .491).Conclusions: In this population-based study, the AGTR1 A1166C polymorphism was associated with LVH, dependent on concomitant renal dysfunction. A weaker renal function dependent association between the ACE I/D polymorphism and LVH was also observed. Renal function should be taken into account as a relevant environmental factor for the pathogenetic effects of RAS polymorphisms. |
| اللغة: | English |
| تدمد: | 0895-7061 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53d43bb861602b7187d9126a0a4302dfTest https://doi.org/10.1016/j.amjhyper.2007.04.023Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....53d43bb861602b7187d9126a0a4302df |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 08957061 |
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