Sex-specific associations of TCF7L2 variants with fasting glucose, type 2 diabetes and coronary heart disease among Turkish adults
| العنوان: | Sex-specific associations of TCF7L2 variants with fasting glucose, type 2 diabetes and coronary heart disease among Turkish adults |
|---|---|
| المؤلفون: | Reijo Laaksonen, Günay Can, Mika Kähönen, Evrim Komurcu-Bayrak, Ayse Berna Yuzbasıogulları, Altan Onat, Nihan Erginel-Unaltuna, Nina Mononen, Terho Lehtimäki |
| المساهمون: | İÜC, Cerrahpaşa Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Tampere University, Clinical Medicine, Department of Clinical Chemistry, Department of Clinical Physiology and Nuclear Medicine |
| المصدر: | Anatolian Journal of Cardiology, Vol 24, Iss 5, Pp 326-333 (2020) Anatolian Journal of Cardiology |
| بيانات النشر: | KARE Publishing, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Blood Glucose, Male, medicine.medical_specialty, endocrine system, lcsh:Diseases of the circulatory (Cardiovascular) system, Turkey, endocrine system diseases, Type 2 diabetes, Coronary Artery Disease, tarf study, 3121 Internal medicine, White People, Internal medicine, Diabetes mellitus, Genotype, medicine, Humans, Genetic Predisposition to Disease, Allele, Risk factor, coronary heart disease, Original Investigation, variants, business.industry, tcf7l2, Haplotype, Gender Identity, nutritional and metabolic diseases, Fasting, Middle Aged, medicine.disease, 3126 Surgery, anesthesiology, intensive care, radiology, Obesity, TCF7L2, Diabetes Mellitus, Type 2, lcsh:RC666-701, Female, type 2 diabetes, Cardiology and Cardiovascular Medicine, business, TARF study, Transcription Factor 7-Like 2 Protein |
| الوصف: | WOS:000583273800010 PubMed ID: 33122478 Objective: TCF7L2 is a repressor and transactivator of genes, and its variants are strongly associated with diabetes. This study aimed to evaluate the sex-specific relationship between the most common TCF7L2 gene variants (-98368G>T, rs12255372 and -47833C>T, rs7903146) with diabetes and coronary heart disease in Turkish Adult Risk Factor (TARF) Study. Methods: Single nucleotide variants (SNVs) have been genotyped using the TaqMan allelic discrimination assays in 2,024 (51.3% in women, age: 55 +/- 11.8) Turkish adults participating in the TARF study. Statistical analyses were used to investigate the association of genotypes with clinical and biochemical measurements. Results: Among the TARF study participants, 11.7%, 24.3%, 14.1%, and 38.3% had diabetes, hypertension, coronary heart disease (CHD), and obesity, respectively. The frequencies of T allele for -47833C>T and -98368G>T in Turkish adults were determined to be 0.35 and 0.33, respectively. -47833C>T was significantly associated with higher fasting glucose concentrations in all participants, especially in men. Both SNVs were significantly associated with diabetes and CHD in all participants (pT was associated with diabetes in women (p=0.041) and -47833C>T was associated with diabetes and CHD in men (p=0.018 and p=0.032, respectively). Also, both SNVs and the diplotypes of common haplotype (H1) remained strongly associated with type 2 diabetes after risk factors were adjusted (p |
| وصف الملف: | application/pdf; fulltext |
| اللغة: | English |
| تدمد: | 2149-2263 0005-8327 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53b706f5830b654738cd260c0d410365Test https://jag.journalagent.com/z4/download_fulltext.asp?pdir=anatoljcardiol&un=AJC-57736Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....53b706f5830b654738cd260c0d410365 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 21492263 00058327 |
|---|