Causes of diabetic ketoacidosis among adults with type 1 diabetes mellitus: insulin pump users and non-users
| العنوان: | Causes of diabetic ketoacidosis among adults with type 1 diabetes mellitus: insulin pump users and non-users |
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| المؤلفون: | Suleiman Alashi, Monica Flores, Ramsha Ahmed, Xiaofeng Wang, M. Cecilia Lansang, Manshi Li, Maryam Amir, Mohammed Al-Jaghbeer |
| المصدر: | BMJ Open Diabetes Research & Care BMJ Open Diabetes Research & Care, Vol 8, Iss 2 (2020) |
| بيانات النشر: | BMJ Publishing Group, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Insulin pump, Pediatrics, medicine.medical_specialty, Diabetic ketoacidosis, endocrine system diseases, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, 030209 endocrinology & metabolism, lcsh:Diseases of the endocrine glands. Clinical endocrinology, Diabetic Ketoacidosis, 03 medical and health sciences, 0302 clinical medicine, Insulin Infusion Systems, Diabetes mellitus, DKA, Surveys and Questionnaires, medicine, adults, Humans, Insulin, 030212 general & internal medicine, Type 1 diabetes, lcsh:RC648-665, business.industry, nutritional and metabolic diseases, medicine.disease, Diabetes Mellitus, Type 1, insulin pump, Etiology, Observational study, Epidemiology/Health services research, Complication, business, insulin-deficient type 1 diabetes |
| الوصف: | IntroductionInsulin pumps are increasingly being used as a method of insulin delivery in patients with type 1 diabetes mellitus (T1DM). Diabetic ketoacidosis (DKA) is a serious complication of T1DM. This study aims to identify the causes of DKA in patients with T1DM on continuous subcutaneous insulin infusion (CSII) and to compare these with patients with T1DM on multiple daily insulin injections (MDIIs).Research design and methodsThis is a prospective observational study between January and June 2019 at the Cleveland Clinic Fairview Hospital. Demographic, clinical, and biochemical data were obtained from chart review. A questionnaire to explore additional clinical data relating to DKA was administered, with additional items for patients on the insulin pump.ResultsSeventy-four patients were admitted with a diagnosis of DKA between the period of January and June 2019. Of these, 45 met the inclusion criteria and 43 consented. These were divided into two groups: group 1 included patients on MDII and group 2 included CSII. Overall, the most common precipitating factor for developing DKA was insulin non-adherence, seen in 51.2% of the cases. The most common cause of DKA in group 2 was pump/tubing related to 55% of the cases.ConclusionDespite non-adherence being common in both CSII and MDII, a combination of social factors, education and insulin pump malfunction, such as pump/tubing problems, might be playing a pivotal role in DKA etiology in young adults with T1DM, especially in CSII users. Continued education on pump use may reduce the rate of DKA in pump users. |
| اللغة: | English |
| تدمد: | 2052-4897 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::526dc0d14ab9b5de8815d87b49a9bb44Test http://europepmc.org/articles/PMC7737023Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....526dc0d14ab9b5de8815d87b49a9bb44 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20524897 |
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