Breast adipocyte size associates with ipsilateral invasive breast cancer risk after ductal carcinoma in situ
| العنوان: | Breast adipocyte size associates with ipsilateral invasive breast cancer risk after ductal carcinoma in situ |
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| المؤلفون: | Annegien Broeks, Jelle Wesseling, Joyce Sanders, Tycho Bismeijer, Esther H. Lips, Ingrid Hofland, Bram Thijssen, Mathilde M. Almekinders, Christine Desmedt, Edoardo Isnaldi, Michael Schaapveld, Marjolijn Mertz, Lodewyk F. A. Wessels, Wilbert Zwart, Erik Hooijberg, Lindy L. Visser |
| المساهمون: | CCA - Cancer biology and immunology, Pathology |
| المصدر: | NPJ Breast Cancer npj Breast Cancer, 7(1):31. Nature Publishing Group Grand Challenge PRECISION consortium 2021, ' Breast adipocyte size associates with ipsilateral invasive breast cancer risk after ductal carcinoma in situ ', npj Breast Cancer, vol. 7, no. 1, 31 . https://doi.org/10.1038/s41523-021-00232-wTest npj Breast Cancer, Vol 7, Iss 1, Pp 1-10 (2021) |
| بيانات النشر: | nature publishing group, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Cancer microenvironment, 0301 basic medicine, Oncology, medicine.medical_specialty, AROMATASE EXPRESSION, medicine.medical_treatment, POPULATION-BASED COHORT, Population, LOCAL RECURRENCE, ADIPOSE INFLAMMATION, Article, Tumour biomarkers, Prognostic markers, 03 medical and health sciences, Breast cancer, 0302 clinical medicine, CONSERVING THERAPY, Internal medicine, Breast-conserving surgery, medicine, Pharmacology (medical), Radiology, Nuclear Medicine and imaging, Overdiagnosis, skin and connective tissue diseases, education, METAANALYSIS, RC254-282, education.field_of_study, Science & Technology, business.industry, WOMEN, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Odds ratio, Ductal carcinoma, medicine.disease, BODY-MASS INDEX, 030104 developmental biology, Risk factors, TISSUE, OBESITY, 030220 oncology & carcinogenesis, Cohort, Immunohistochemistry, business, Life Sciences & Biomedicine |
| الوصف: | Although ductal carcinoma in situ (DCIS) is a non-obligate precursor to ipsilateral invasive breast cancer (iIBC), most DCIS lesions remain indolent. Hence, overdiagnosis and overtreatment of DCIS is a major concern. There is an urgent need for prognostic markers that can distinguish harmless from potentially hazardous DCIS. We hypothesised that features of the breast adipose tissue may be associated with risk of subsequent iIBC. We performed a case–control study nested in a population-based DCIS cohort, consisting of 2658 women diagnosed with primary DCIS between 1989 and 2005, uniformly treated with breast conserving surgery (BCS) alone. We assessed breast adipose features with digital pathology (HALO®, Indica Labs) and related these to iIBC risk in 108 women that developed subsequent iIBC (cases) and 168 women who did not (controls) by conditional logistic regression, accounting for clinicopathological and immunohistochemistry variables. Large breast adipocyte size was significantly associated with iIBC risk (odds ratio (OR) 2.75, 95% confidence interval (95% CI) = 1.25–6.05). High cyclooxygenase (COX)-2 protein expression in the DCIS cells was also associated with subsequent iIBC (OR 3.70 (95% CI = 1.59–8.64). DCIS with both high COX-2 expression and large breast adipocytes was associated with a 12-fold higher risk (OR 12.0, 95% CI = 3.10–46.3, P |
| وصف الملف: | application/pdf; Electronic |
| اللغة: | English |
| تدمد: | 2374-4677 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::526892f6d092cee679dd4d9ab2f25453Test https://hdl.handle.net/1887/3627225Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....526892f6d092cee679dd4d9ab2f25453 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 23744677 |
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