Angiotensin II type 1 receptor blockers favorably affect renal angiotensin II and MAS receptor expression in patients with diabetic nephropathy
| العنوان: | Angiotensin II type 1 receptor blockers favorably affect renal angiotensin II and MAS receptor expression in patients with diabetic nephropathy |
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| المؤلفون: | Yi-ning Wang, Ye-Ping Ma, Yue Yang, Wenge Li, Lin Liu, Zheng Zhang, Guming Zou, Shimin Jiang |
| المصدر: | Journal of the Renin-Angiotensin-Aldosterone System: JRAAS Journal of the Renin-Angiotensin-Aldosterone System, Vol 21 (2020) |
| بيانات النشر: | SAGE Publications, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Male, Angiotensin receptor, Medicine (General), Biopsy, 030232 urology & nephrology, Diabetic nephropathy, 030204 cardiovascular system & hematology, Angiotensin II Type 1 Receptor Blockers, Kidney, Proto-Oncogene Mas, angiotensin II type 1 receptor blocker, Receptors, G-Protein-Coupled, 0302 clinical medicine, Endocrinology, Diabetic Neuropathies, Receptor, medicine.diagnostic_test, Angiotensin II, Mas receptor, Middle Aged, Kidney Tubules, immunohistochemistry, Immunohistochemistry, Original Article, Female, Renal biopsy, hormones, hormone substitutes, and hormone antagonists, Adult, medicine.medical_specialty, Adolescent, Receptor, Angiotensin, Type 2, Receptor, Angiotensin, Type 1, 03 medical and health sciences, Young Adult, R5-920, renal biopsy, Internal medicine, Proto-Oncogene Proteins, Internal Medicine, medicine, Humans, Aged, business.industry, angiotensin receptor, medicine.disease, business |
| الوصف: | Introduction:The aims of this study were to assess the renal expression of angiotensin II type 1 receptor (AT1R), angiotensin II type 2 receptor (AT2R), and MAS receptor in human type 2 diabetic nephropathy (DN).Materials and methods:In total, 115 patients diagnosed with DN by renal biopsy were enrolled in this study. The protein expression levels of the AT1R, AT2R, and MAS receptors were assessed by immunohistochemistry.Results:The protein expression levels of AT1R, AT2R, and MAS receptor in the renal biopsy tissue were correlated with the pathologic classification of DN. Tubulointerstitial AT1R expression in patients of class IIb was significantly stronger than control samples ( p < 0.05). Expression of AT2R and MAS receptors were highest with class IIb DN patients. When DN patients were treated with AT1R blocker (ARB), the expression of AT1R was downregulated ( p < 0.05), and the MAS receptor was upregulated in tubular interstitial ( p < 0.05).Conclusions:Our results directly observed that renal expression levels of AT1R increase during the early stages of DN, ARB reducing AT1R while increasing MAS receptor. Therefore, ARB should be used as soon as possible in patients with DN. |
| اللغة: | English |
| تدمد: | 1752-8976 1470-3203 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::526324dc645526c086dbbfa89629d2c0Test http://europepmc.org/articles/PMC7227143Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....526324dc645526c086dbbfa89629d2c0 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17528976 14703203 |
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