Long non-coding RNA FOXD2-AS1 plays an oncogenic role in hepatocellular carcinoma by targeting miR‑206
| العنوان: | Long non-coding RNA FOXD2-AS1 plays an oncogenic role in hepatocellular carcinoma by targeting miR‑206 |
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| المؤلفون: | Guanghui Wang, Xuqi Li, Cancan Zhou, Xinming Chang, Guanglin Qiu, Jie Zhang, Shufeng Wang, Yuanhong Chang, Lin Fan |
| المصدر: | Oncology Reports. |
| بيانات النشر: | Spandidos Publications, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, Cancer Research, Carcinoma, Hepatocellular, Cell, Biology, medicine.disease_cause, Mice, 03 medical and health sciences, 0302 clinical medicine, Cell Movement, Cell Line, Tumor, medicine, Animals, Humans, Annexin A2, Regulation of gene expression, Oncogene, Liver Neoplasms, RNA, General Medicine, Prognosis, Survival Analysis, Long non-coding RNA, Up-Regulation, Gene Expression Regulation, Neoplastic, MicroRNAs, 030104 developmental biology, medicine.anatomical_structure, Oncology, Tumor progression, 030220 oncology & carcinogenesis, Cancer research, Female, RNA, Long Noncoding, Carcinogenesis |
| الوصف: | Recently, long non-coding RNA (lncRNA) FOXD2 adjacent opposite strand RNA 1 (FOXD2-AS1) has been recognized to function as an oncogene in several human tumors, and FOXD2‑AS1 dysregulation has been closely associated with carcinogenesis and tumor progression. Nevertheless, the correlation between the aberrant expression of FOXD2‑AS1 and the prognosis of hepatocellular carcinoma (HCC) has not yet been elucidated. In the present study, FOXD2‑AS1 was found to be overexpressed in HCC tissues, and FOXD2‑AS1 overexpression resulted in significantly shortened patient survival. FOXD2‑AS1 overexpression enhanced the viability and metastasis of HCC cells in vitro and in vivo, as revealed by MTT, wound healing and cell migration assays. In addition, mechanistic studies revealed that FOXD2‑AS1 upregulated the expression of the miR‑206 target gene annexin A2 (ANXA2) by acting as a miR‑206 sponge. In summary, FOXD2‑AS1 was concluded to function as an oncogene in HCC and to upregulate ANXA2 expression in part by 'sponging' miR‑206. |
| تدمد: | 1791-2431 1021-335X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5224fa8824903264dc14291d8e23a0b3Test https://doi.org/10.3892/or.2018.6752Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....5224fa8824903264dc14291d8e23a0b3 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17912431 1021335X |
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