Trimethylamine-N-oxide: A Novel Biomarker for the Identification of Inflammatory Bowel Disease
| العنوان: | Trimethylamine-N-oxide: A Novel Biomarker for the Identification of Inflammatory Bowel Disease |
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| المؤلفون: | Rommel G. Tirona, Sarah Woolsey, Marianne K. DeGorter, Bridget L. Morse, Wendy A. Teft, Richard B. Kim, Robert A. Hegele, Aze Wilson, Yun-Hee Choi |
| المصدر: | Digestive Diseases and Sciences. 60:3620-3630 |
| بيانات النشر: | Springer Science and Business Media LLC, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Adolescent, Physiology, Population, Trimethylamine N-oxide, Biology, Gastroenterology, Inflammatory bowel disease, Methylamines, Young Adult, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Internal medicine, medicine, Humans, Choline, Microbiome, Carnitine, education, Aged, 030304 developmental biology, Aged, 80 and over, 0303 health sciences, education.field_of_study, Hepatology, business.industry, Middle Aged, Inflammatory Bowel Diseases, medicine.disease, Ulcerative colitis, digestive system diseases, 3. Good health, chemistry, Case-Control Studies, Cancer research, Biomarker (medicine), Identification (biology), Female, 030211 gastroenterology & hepatology, business, Biomarkers, medicine.drug |
| الوصف: | The gastrointestinal (GI) microbiome is recognized for potential clinical relevance in inflammatory bowel disease (IBD). Data suggest that there is a disease-dependent loss of microbial diversity in IBD. Trimethylamine-N-oxide (TMAO) is generated by GI anaerobes through the digestion of dietary phosphatidylcholine and carnitine in a microbial-mammalian co-metabolic pathway. IBD-related changes in the gut microbiome may result in disease-specific changes in TMAO plasma concentrations. To determine whether TMAO plasma levels in IBD are altered compared to controls and whether they correlate with disease presence or activity. Liquid chromatography–tandem mass spectrometry was used to measure TMAO, choline, and carnitine plasma levels in 479 subjects (373 non-IBD controls, 106 IBD). Subjects were also genotyped for the flavin monooxygenase (FMO)3 variants, E158K and E308G. Plasma TMAO levels were 2.27 µM lower in the IBD population compared to the control population (p = 0.0001). Lower TMAO levels were similarly seen in active ulcerative colitis (UC) (1.56 µM) versus inactive disease (3.40 µM) (p = 0.002). No difference was seen in active Crohn’s disease (CD) versus inactive CD. No intergroup variation existed in plasma TMAO levels based on FMO3 genotype. Choline levels were higher in IBD, while carnitine levels were similar between the two groups, suggesting that lower TMAO levels in IBD were not due to dietary differences. Decreased TMAO levels are seen in IBD compared to a non-IBD population. These data suggest that TMAO may have potential as a biomarker to support IBD diagnosis as well as to assess disease activity in UC. |
| تدمد: | 1573-2568 0163-2116 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5198960867fef2146ac877bf2e74a849Test https://doi.org/10.1007/s10620-015-3797-3Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....5198960867fef2146ac877bf2e74a849 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15732568 01632116 |
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