Circulating soluble CD36 is similar in type 1 and type 2 diabetes mellitus versus non-diabetic subjects
| العنوان: | Circulating soluble CD36 is similar in type 1 and type 2 diabetes mellitus versus non-diabetic subjects |
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| المؤلفون: | Didac Mauricio, Esmeralda Castelblanco, Mireia Falguera, Lucía Sanjurjo, Marta Hernández, José Manuel Fernández-Real, Núria Alonso, Maria-Rosa Sarrias |
| المصدر: | Journal of Clinical Medicine r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau instname Repositorio Abierto de la UdL Universitad de Lleida Journal of Clinical Medicine, Vol 8, Iss 5, p 710 (2019) Recercat. Dipósit de la Recerca de Catalunya r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol Volume 8 Issue 5 Journal of Clinical Medicine, 2019, vol. 8, núm. 5, p. 710 Articles publicats (IdIBGi) DUGiDocs – Universitat de Girona |
| بيانات النشر: | MDPI, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | endocrine system diseases, estimated glomerular filtration rate, type 2 diabetes mellitus, CD36, lcsh:Medicine, Type 2 diabetes, Blood plasma, 030204 cardiovascular system & hematology, Logistic regression, Gastroenterology, Diabetis no-insulinodependent, hydroxymethylglutaryl coenzyme A reductase inhibitor, 0302 clinical medicine, CD36 antigen, gender, Non-insulin-dependent diabetes, Diabetis, biology, non insulin dependent diabetes mellitus, adult, Diabetes, General Medicine, cohort analysis, aged, female, real time polymerase chain reaction, Non diabetic, medicine.medical_specialty, hypertension, hematocrit, Type 1 diabetes mellitus, 030209 endocrinology & metabolism, oral antidiabetic agent, insulin dependent diabetes mellitus, Article, smoking, 03 medical and health sciences, male, Internal medicine, Diabetes mellitus, Type 2 diabetes mellitus, medicine, controlled study, human, protein expression, Type 1 diabetes, mean platelet volume, business.industry, flow cytometry, lcsh:R, disease association, dyslipidemia, Type 2 Diabetes Mellitus, nutritional and metabolic diseases, Plasma sanguini, platelet count, medicine.disease, sCD36, major clinical study, body mass, enzyme linked immunosorbent assay, biology.protein, gene expression, mRNA expression level, business, type 1 diabetes mellitus |
| الوصف: | The aim of this study was to determine whether plasma concentrations of sCD36 (soluble CD36) are associated with the presence of type 1 or type 2 diabetes. Plasma levels of sCD36 were analysed in 1023 subjects (225 type 1 diabetes (T1D) patients, 276 type 2 diabetes (T2D) patients, and 522 non-diabetic control subjects) using an enzyme-linked immunosorbent assay (ELISA). Multinomial and logistic regression models were performed to evaluate associations with sCD36 and its association with diabetes types. There were no significant differences in sCD36 (p = 0.144) among study groups, neither in head-to-head comparisons: non-diabetic versus T1D subjects (p = 0.180), non-diabetic versus T2D subjects (p = 0.583), and T1D versus T2D patients (p = 0.151). In the multinomial model, lower sCD36 concentrations were associated with older age (p < 0.001), tobacco exposure (p = 0.006), T2D (p = 0.020), and a higher-platelets count (p = 0.004). However, in logistic regression models of diabetes, sCD36 showed only a weak association with T2D. The current findings show a weak association of circulating sCD36 with type 2 diabetes and no association with T1D. |
| وصف الملف: | application/pdf |
| تدمد: | 2077-0383 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51842d5a00a26aadb4262a8947ac9de3Test https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=10258Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....51842d5a00a26aadb4262a8947ac9de3 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20770383 |
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