Role of Lung Function Genes in the Development of Asthma
| العنوان: | Role of Lung Function Genes in the Development of Asthma |
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| المؤلفون: | Tohru Sakamoto, Yohei Yatagai, Emiko Noguchi, Masaharu Nishimura, Yoshiko Kaneko, Hironori Masuko, Hiroaki Iijima, Hideyasu Yamada, Nobuyuki Hizawa, Tomomitsu Hirota, Takashi Naito, Satoshi Konno, Mayumi Tamari |
| المصدر: | PLoS ONE, Vol 11, Iss 1, p e0145832 (2016) PLoS ONE |
| بيانات النشر: | Public Library of Science (PLoS), 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | 0301 basic medicine, Adult, Male, Risk, Genotype, Vital Capacity, lcsh:Medicine, Genome-wide association study, Biology, Polymorphism, Single Nucleotide, Pulmonary function testing, Cohort Studies, 03 medical and health sciences, FEV1/FVC ratio, Pulmonary Disease, Chronic Obstructive, 0302 clinical medicine, Quantitative Trait, Heritable, Japan, Forced Expiratory Volume, medicine, Genetic predisposition, Humans, Genetic Predisposition to Disease, Age of Onset, lcsh:Science, Lung, Asthma, Aged, Genetics, Multidisciplinary, lcsh:R, Heritability, Middle Aged, medicine.disease, Genetic load, respiratory tract diseases, 030104 developmental biology, 030228 respiratory system, Immunology, Female, lcsh:Q, Age of onset, Research Article, Genome-Wide Association Study |
| الوصف: | Although our previous GWAS failed to identify SNPs associated with pulmonary function at the level of genomewide significance, it did show that the heritability for FEV1/FVC was 41.6% in a Japanese population, suggesting that the heritability of pulmonary function traits can be explained by the additive effects of multiple common SNPs. In addition, our previous study indicated that pulmonary function genes identified in previous GWASs in non-Japanese populations accounted for 4.3% to 12.0% of the entire estimated heritability of FEV1/FVC in a Japanese population. Therefore, given that many loci with individual weak effects may contribute to asthma risk, in this study, we created a quantitative score of genetic load based on 16 SNPs implicated in lower lung function in both Japanese and non-Japanese populations. This genetic risk score (GRS) for lower FEV1/FVC was consistently associated with the onset of asthma (P = 9.6 × 10(-4)) in 2 independent Japanese populations as well as with the onset of COPD (P = 0.042). Clustering of asthma patients based on GRS levels indicated that an increased GRS may be responsible for the development of a particular phenotype of asthma characterized by early onset, atopy, and severer airflow obstruction. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1932-6203 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51736e808ac6e239df3a24ad23647968Test http://europepmc.org/articles/PMC4709100?pdf=renderTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....51736e808ac6e239df3a24ad23647968 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19326203 |
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