Tryptophan levels associate with incident cardiovascular disease in chronic kidney disease
| العنوان: | Tryptophan levels associate with incident cardiovascular disease in chronic kidney disease |
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| المؤلفون: | Anna V. Mathew, Keith Bellovich, Thekkelnaycke M. Rajendiran, Crystal A. Gadegbeku, Vetalise C Konje, Debbie S. Gipson, Farsad Afshinnia |
| المصدر: | Clinical Kidney Journal |
| بيانات النشر: | Oxford University Press, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | medicine.medical_specialty, Kynurenine pathway, medicine.medical_treatment, Population, 030204 cardiovascular system & hematology, Systemic inflammation, Gastroenterology, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Internal medicine, medicine, cardiovascular diseases, education, AcademicSubjects/MED00340, Dialysis, 030304 developmental biology, 0303 health sciences, Transplantation, education.field_of_study, Proteinuria, business.industry, Area under the curve, Original Articles, medicine.disease, metabolomics, indoleamine dioxygenase, kynurenine, chemistry, Nephrology, inflammation, medicine.symptom, business, Kynurenine, Kidney disease |
| الوصف: | Background Non-traditional risk factors like inflammation and oxidative stress play an essential role in the increased cardiovascular disease (CVD) risk prevalent in chronic kidney disease (CKD). Tryptophan catabolism by the kynurenine pathway (KP) is linked to systemic inflammation and CVD in the general and dialysis population. However, the relationship of KP to incident CVD in the CKD population is unknown. Methods We measured tryptophan metabolites using targeted mass spectrometry in 92 patients with a history of CVD (old CVD); 46 patients with no history of CVD and new CVD during follow-up (no CVD); and 46 patients with no CVD history who developed CVD in the median follow-up period of 2 years (incident CVD). Results The three groups are well-matched in age, gender, race, diabetes status and CKD stage, and only differed in total cholesterol and proteinuria. Tryptophan and kynurenine levels significantly decreased in patients with ‘Incident CVD’ compared with the no CVD or old CVD groups (P = 5.2E–7; P = 0.003 respectively). Kynurenic acid, 3-hydroxykynurenine and kynurenine are all increased with worsening CKD stage (P Conclusions In summary, our study demonstrates that low tryptophan levels are associated with incident CVD in CKD. |
| اللغة: | English |
| تدمد: | 2048-8513 2048-8505 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5155889eabb3c586464622982de58296Test http://europepmc.org/articles/PMC8173620Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....5155889eabb3c586464622982de58296 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20488513 20488505 |
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