Correlation of hypertension and proteinuria with outcome in elderly bevacizumab treated patients with metastatic colorectal cancer
| العنوان: | Correlation of hypertension and proteinuria with outcome in elderly bevacizumab treated patients with metastatic colorectal cancer |
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| المؤلفون: | Ramon Perez-Carrion, Jaime Feliu, Alberto Carmona, Maria Jose Safont, Ana Custodio, Joan Maurel, Ferran Losa, Carlos Bosch, Pilar Escudero, Jorge Aparicio, Mónica Jorge, Carlos García-Girón, Antonieta Salud, Uriel Bohn, Enrique Casado |
| المساهمون: | [Feliu, Jaime, Custodio, Ana B.] Hosp Univ La Paz, Serv Oncol Med, Madrid, Spain, [Casado, Enrique] Hosp Infanta Sofia, Serv Oncol Med, Madrid, Spain |
| المصدر: | PLoS ONE, Vol 10, Iss 1, p e0116527 (2015) Plos One r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe instname Repositorio Abierto de la UdL Universitad de Lleida PLoS ONE Recercat. Dipósit de la Recerca de Catalunya Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid Consejería de Sanidad de la Comunidad de Madrid |
| بيانات النشر: | Public Library of Science, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Oncology, Male, Pathology, genetic structures, Organoplatinum Compounds, Colorectal cancer, Secondary hypertension, lcsh:Medicine, Deoxycytidine, Metastasis, Antineoplastic Combined Chemotherapy Protocols, lcsh:Science, Aged, 80 and over, Multidisciplinary, Proteinuria, humanities, Bevacizumab, Oxaliplatin, Treatment Outcome, Hypertension, Female, Fluorouracil, medicine.symptom, Colorectal Neoplasms, medicine.drug, Research Article, medicine.medical_specialty, Antibodies, Monoclonal, Humanized, Disease-Free Survival, Clinical Trials, Phase II as Topic, Internal medicine, medicine, Humans, Capecitabine, Aged, Retrospective Studies, business.industry, lcsh:R, Retrospective cohort study, medicine.disease, eye diseases, digestive system diseases, Clinical trial, Multivariate Analysis, lcsh:Q, business |
| الوصف: | Background Studies suggest a relationship between hypertension and outcome in bevacizumab-treated patients with metastatic colorectal cancer (mCRC). We performed a retrospective analysis of two phase II studies (BECA and BECOX) to determine if hypertension and proteinuria predict outcome in elderly patients with mCRC treated with bevacizumab. Patients and Methods Patients >= 70 years of age received either capecitabine 1250 mg/m(2) bid days 1-14 + bevacizumab 7.5 mg/kg day 1 every 21 days (BECA study) or capecitabine 1000 mg/m(2) bid days 1-14 with bevacizumab 7.5 mg/kg and oxaliplatin 130 mg/m(2) day 1 (BECOX study). The primary objective was to correlate hypertension and proteinuria with overall response rate (ORR), time to progression (TTP) and overall survival (OS). Secondary objectives included identification of risk factors associated with the development of hypertension and proteinuria and determining whether development of hypertension or proteinuria in the first 2 cycles was related to ORR, disease-control rate (DCR), TTP or OS. Results In total, 127 patients (median age 75.5 years) were included in the study. Hypertension correlated with DCR and OS; proteinuria correlated with ORR and DCR. Proteinuria or hypertension in the first 2 cycles did not correlate with efficacy. Risk factors for hypertension were female gender (odds ratio [OR] 0.241; P = 0.011) and more bevacizumab cycles (OR 1.112; P = 0.002); risk factors for proteinuria were diabetes (OR 3.869; P = 0.006) and more bevacizumab cycles (OR 1.181; P |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1932-6203 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fc244abb25d9e1b7665e3986dc7f49fTest https://hdl.handle.net/10459.1/49476Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....4fc244abb25d9e1b7665e3986dc7f49f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19326203 |
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