Use of immune checkpoint inhibitors in cancer patients with pre-existing sarcoidosis
| العنوان: | Use of immune checkpoint inhibitors in cancer patients with pre-existing sarcoidosis |
|---|---|
| المؤلفون: | Maria E. Suarez-Almazor, Manuel Ramos-Casals, Sang T. Kim, Xerxes Pundole, Ramona Dadu, Olivier Lambotte |
| المصدر: | Immunotherapy |
| بيانات النشر: | Future Medicine Ltd, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Adult, Male, 0301 basic medicine, medicine.medical_specialty, Sarcoidosis, Exacerbation, Immunology, Arthritis, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Atezolizumab, Prednisone, Neoplasms, Internal medicine, Humans, Immunology and Allergy, Medicine, Case Series, Adverse effect, Immune Checkpoint Inhibitors, Aged, Retrospective Studies, business.industry, Cancer, Middle Aged, Symptom Flare Up, medicine.disease, 030104 developmental biology, Oncology, 030220 oncology & carcinogenesis, Female, business, Uveitis, medicine.drug |
| الوصف: | Aim: To evaluate adverse events in cancer patients with pre-existing sarcoidosis receiving immune checkpoint inhibitors (ICIs). Patients & methods: We retrospectively reviewed cancer patients with sarcoidosis who underwent treatment with ICI to determine frequency of sarcoidosis flares. Results: 32 patients with sarcoidosis received ICIs The median time to ICI initiation was 7 years (range: 1 month to 51 years). One patient (3%) with a 20-year remote history of sarcoidosis developed a clinically symptomatic exacerbation after three doses of atezolizumab, with hilar lymphadenopathy, subcutaneous nodules, arthritis and uveitis. Atezolizumab was discontinued and prednisone initiated. She had a fluctuating course with two additional flares. Conclusion: Frequency of flares in patients with a remote history of sarcoidosis who receive ICIs is low. |
| تدمد: | 1750-7448 1750-743X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fbe7cab36fe034725c234bbc92596cfTest https://doi.org/10.2217/imt-2020-0272Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....4fbe7cab36fe034725c234bbc92596cf |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17507448 1750743X |
|---|