Impact of sepsis on levels of plasma cystatin C in AKI and non-AKI patients
| العنوان: | Impact of sepsis on levels of plasma cystatin C in AKI and non-AKI patients |
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| المؤلفون: | Anders Oldner, Max Bell, Johan Mårtensson, Claes-Roland Martling |
| المصدر: | Nephrology Dialysis Transplantation. 27:576-581 |
| بيانات النشر: | Oxford University Press (OUP), 2011. |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | Male, urologic and male genital diseases, Systemic inflammation, Gastroenterology, law.invention, Cohort Studies, chemistry.chemical_compound, law, Medicine, Child, biology, Acute kidney injury, Acute Kidney Injury, Middle Aged, Intensive care unit, female genital diseases and pregnancy complications, Survival Rate, Intensive Care Units, C-Reactive Protein, Nephrology, Area Under Curve, Creatinine, Disease Progression, Female, Cystatin, medicine.symptom, Adult, medicine.medical_specialty, Adolescent, Critical Care, Critical Illness, Sensitivity and Specificity, Sepsis, Young Adult, Predictive Value of Tests, Internal medicine, Humans, Cystatin C, Survival rate, Aged, Analysis of Variance, Transplantation, urogenital system, business.industry, Body Weight, medicine.disease, ROC Curve, chemistry, Case-Control Studies, biology.protein, business, Biomarkers |
| الوصف: | Background Cystatin C is a marker of acute kidney injury (AKI). However, systemic inflammation associated with sepsis, a common AKI-trigger, may affect cystatin C. We studied the impact of sepsis on cystatin C levels in plasma. Furthermore, we investigated whether the presence of sepsis affects the predictive properties of cystatin C. Methods Three hundred and twenty-seven intensive care unit (ICU) patients were categorized as having: neither AKI nor sepsis (n = 151), sepsis without AKI (n = 80), AKI without sepsis (n = 24) or AKI and sepsis (n = 72) during their first week in the ICU. Changes in cystatin C and creatinine over time in patients with and without sepsis or AKI were analysed using repeated measures analysis of variance. The performance of cystatin C on admission to predict sustained AKI, worsened AKI or death was assessed from the area under the receiver-operating characteristic curve (AUC-ROC) in septic and non-septic patients separately. Results In non-AKI patients, cystatin C increased and creatinine decreased significantly over the first week. The change in cystatin C or creatinine did not differ significantly between septic and non-septic patients without AKI. Even in AKI patients, the cystatin C change did not differ significantly between septic and non-septic patients. The AUC-ROCs for prediction of the composite outcome were 0.80 and 0.78 in patients with and without sepsis, respectively, and did not differ significantly (P = 0.76). Conclusion The inflammatory response induced by sepsis has no impact on the levels of cystatin C in plasma during the first week in the ICU. |
| تدمد: | 1460-2385 0931-0509 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fb13ed9fe8487ea01e12105e9c6d964Test https://doi.org/10.1093/ndt/gfr358Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....4fb13ed9fe8487ea01e12105e9c6d964 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14602385 09310509 |
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