No genetic support for a contribution of prostaglandins to the aetiology of androgenetic alopecia
| العنوان: | No genetic support for a contribution of prostaglandins to the aetiology of androgenetic alopecia |
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| المؤلفون: | Heilmann, S., Nyholt, D. R., Bataille, V., Brockschmidt, F. F., Dedoussis, G., Deloukas, P., den Heijer, M., Dimitriou, M., Eigelshoven, S., Eriksson, N., Geller, F., Glass, D., Hanneken, S., Heath, A. C., Hillmer, A. M., Hinds, D. A., Kanoni, S., Kárason, A., Kiefer, A. K., Kiemeney, L. A., Li, R., Mangino, M., Martin, N. G., Medland, S. E., Moebus, S., Montgomery, G. W., Mooser, V., Richards, J. B., Song, K., Spector, T. D., Herold, C., Stefansson, H., Stefansson, K., Sulem, P., Tung, J. Y., Vermeulen, S. H., Vollenweider, P., Waterworth, D., Consortium, Maan, Becker, T., Nöthen, M. M., Consortium, Meta-Analysis for Androgenetic Alopecia Novel Determinants |
| المصدر: | British Journal of Dermatology, 169, 222-4 British Journal of Dermatology, 169, 1, pp. 222-4 British journal of dermatology 169(1), 222-224 (2013). doi:10.1111/bjd.12292 |
| بيانات النشر: | Oxford University Press (OUP), 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Candidate gene, Receptors, Prostaglandin, Genome-wide association study, Aetiology, screening and detection [ONCOL 5], Dermatology, Disease, Biology, Molecular epidemiology [NCEBP 1], Genetic predisposition, medicine, genetics [Receptors, Immunologic], Humans, ddc:610, Receptors, Immunologic, genetics [Alopecia], Molecular epidemiology Aetiology, screening and detection [NCEBP 1], Genetic association, genetics [Prostaglandin D2], Genetics, Prostaglandin D2, Alopecia, medicine.disease, Phenotype, genetics [Receptors, Prostaglandin], Hair loss, metabolism [Prostaglandin D2], Trait, prostaglandin D2 receptor |
| الوصف: | MADAM, Androgenetic alopecia (AGA) is a common age-dependent trait, characterized by a progressive loss of hair from the scalp. The hair loss may commence during puberty and up to 80% of white men experience some degree of AGA during their lifetime.1 Research has established that two essential aetiological factors for AGA are a genetic predisposition and the presence of androgens (male sex hormones).1,2 A recent meta-analysis of genome-wide association studies (GWAS) has increased the number of identified loci associated with this trait at the molecular level to a total of eight.3 However, despite these successes, a large fraction of the genetic contribution remains to be identified. One way to identify further genetic loci is to combine the resource of GWAS datasets with knowledge about specific biological factors likely to be involved in the development of disease. The focused evaluation of a limited number of candidate genes in GWAS datasets avoids the necessity for extensive correction for multiple testing, which typically limits the power for detecting genetic loci at a genome-wide level.4 Because the presence of genetic association suggests that candidate genes are likely to operate early in the causative chain of events leading to the phenotype, this approach may also function to favour biological pathways for their importance in the development of AGA. |
| تدمد: | 0007-0963 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f38374302ff1d651901c9bc337d520dTest https://doi.org/10.1111/bjd.12292Test |
| حقوق: | RESTRICTED |
| رقم الانضمام: | edsair.doi.dedup.....4f38374302ff1d651901c9bc337d520d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 00070963 |
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