Elevated serum galectin-1 concentrations are associated with increased risks of mortality and acute kidney injury in critically ill patients
| العنوان: | Elevated serum galectin-1 concentrations are associated with increased risks of mortality and acute kidney injury in critically ill patients |
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| المؤلفون: | Chi Ting Lu, Chuan Tsai Tsai, Po Hsun Huang, Shang Feng Yang, Shu Fen Lu, Cheng Hsueh Wu, Shing Jong Lin, Ya Wen Lu, Yi Lin Tsai, Ru Yu Lien, Jiun Yu Guo, Ruey Hsing Chou |
| المصدر: | PLoS ONE PLoS ONE, Vol 16, Iss 9, p e0257558 (2021) |
| بيانات النشر: | Public Library of Science (PLoS), 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Male, Pulmonology, Galectin 1, Epidemiology, medicine.medical_treatment, Gastroenterology, Medicine and Health Sciences, Multidisciplinary, Cancer Risk Factors, Mortality rate, Hazard ratio, Acute kidney injury, Acute Kidney Injury, Middle Aged, Hospitals, Renal Replacement Therapy, Intensive Care Units, Oncology, Nephrology, Renal Cancer, Medicine, SOFA score, Anatomy, Research Article, Adult, medicine.medical_specialty, Death Rates, Science, Critical Illness, Cardiology, Renal function, Sepsis, Signs and Symptoms, Population Metrics, Internal medicine, medicine, Humans, Renal replacement therapy, Heart Failure, Population Biology, business.industry, Biology and Life Sciences, Kidneys, Pneumonia, Renal System, medicine.disease, Health Care, Health Care Facilities, Medical Risk Factors, Clinical Medicine, business, Kidney disease |
| الوصف: | Background Galectin-1 (Gal-1), a member of the β-galactoside binding protein family, is associated with inflammation and chronic kidney disease. However, the effect of Gal-1 on mortality and acute kidney injury (AKI) in critically-ill patients remain unclear. Methods From May 2018 to March 2020, 350 patients admitted to the medical intensive care unit (ICU) of Taipei Veterans General Hospital, a tertiary medical center, were enrolled in this study. Forty-one patients receiving long-term renal replacement therapy were excluded. Serum Gal-1 levels were determined within 24 h of ICU admission. The patients were divided into tertiles according to their serum Gal-1 levels (low, serum Gal-1 < 39 ng/ml; median, 39–70 ng/ml; high, ≥71 ng/ml). All patients were followed for 90 days or until death. Results Mortality in the ICU and at 90 days was greater among patients with elevated serum Gal-1 levels. In analyses adjusted for the body mass index, malignancy, sepsis, Sequential Organ Failure Assessment (SOFA) score, and serum lactate level, the serum Gal-1 level remained an independent predictor of 90-day mortality [median vs. low: adjusted hazard ratio (aHR) 2.11, 95% confidence interval (CI) 1.24–3.60, p = 0.006; high vs. low: aHR 3.21, 95% CI 1.90–5.42, p < 0.001]. Higher serum Gal-1 levels were also associated with a higher incidence of AKI within 48 h after ICU admission, independent of the SOFA score and renal function (median vs. low: aHR 2.77, 95% CI 1.21–6.34, p = 0.016; high vs. low: aHR 2.88, 95% CI 1.20–6.88, p = 0.017). The results were consistent among different subgroups with high and low Gal-1 levels. Conclusion Serum Gal-1 elevation at the time of ICU admission were associated with an increased risk of mortality at 90 days, and an increased incidence of AKI within 48 h after ICU admission. |
| تدمد: | 1932-6203 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4eef03d31be4963450481a16fe028dc3Test https://doi.org/10.1371/journal.pone.0257558Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....4eef03d31be4963450481a16fe028dc3 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19326203 |
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