Functional assessment of MeCP2 in Rett syndrome and cancers of breast, colon, and prostate
| العنوان: | Functional assessment of MeCP2 in Rett syndrome and cancers of breast, colon, and prostate |
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| المؤلفون: | Kevin Pruitt, Somnath Pandey |
| المصدر: | Biochemistry and Cell Biology. 95:368-378 |
| بيانات النشر: | Canadian Science Publishing, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, congenital, hereditary, and neonatal diseases and abnormalities, Methyl-CpG-Binding Protein 2, Breast Neoplasms, Rett syndrome, medicine.disease_cause, Biochemistry, MECP2, 03 medical and health sciences, Prostate cancer, Breast cancer, Rett Syndrome, medicine, Humans, Molecular Biology, biology, business.industry, Prostatic Neoplasms, Cancer, Cell Biology, medicine.disease, nervous system diseases, Chromatin, 030104 developmental biology, Histone, Colonic Neoplasms, biology.protein, Cancer research, Female, Carcinogenesis, business |
| الوصف: | Ever since the first report that mutations in methyl-CpG-binding protein 2 (MeCP2) causes Rett syndrome (RTT), a severe neurological disorder in females world-wide, there has been a keen interest to gain a comprehensive understanding of this protein. While the classical model associated with MeCP2 function suggests its role in gene suppression via recruitment of co-repressor complexes and histone deacetylases to methylated CpG-sites, recent discoveries have brought to light its role in transcription activation, modulation of RNA splicing, and chromatin compaction. Various post-translational modifications (PTMs) of MeCP2 further increase its functional versatility. Involvement of MeCP2 in pathologies other than RTT, such as tumorigenesis however, remains poorly explored and understood. This review provides a survey of the literature implicating MeCP2 in breast, colon and prostate cancer. |
| تدمد: | 1208-6002 0829-8211 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ebfd3c6049d326f9d566a4b67561351Test https://doi.org/10.1139/bcb-2016-0154Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....4ebfd3c6049d326f9d566a4b67561351 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 12086002 08298211 |
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